NCT01962038CompletedNot Applicable
A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment
Palo Alto Veterans Institute for Research1 site in 1 country72 target enrollmentStarted: May 1, 2013Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Change from Baseline to 28 weeks in delayed recall of a word list
Study Overview
Brief Summary
The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •diagnosis of amnestic Mild Cognitive Impairment
- •available informant
- •visual and auditory acuity to allow neuropsychological testing
- •willingness to participate in exercise training + cognitive training for 8 months
- •approval of primary provider to participate in exercise trial
Exclusion Criteria
- •current severe psychiatric disorder
- •diagnosis of dementia
- •history of neurological or system illness affecting CNS function
- •acute illness or unstable chronic illness
- •current severe cardiac disease
- •inability to exercise consistently because of orthopedic or musculoskeletal problems
- •morbid obesity
- •inability to read, verbalize understanding and voluntarily sign the informed consent
Arms & Interventions
Combined Aerobic and Resistance Exercise/Cognitive Training
Active Comparator
Intervention: Combined Aerobic and Resistance Exercise (Behavioral)
Combined Aerobic and Resistance Exercise/Cognitive Training
Active Comparator
Intervention: Cognitive Training (Behavioral)
Stretching Exercises/Cognitive Training
Active Comparator
Intervention: Stretching Exercises (Behavioral)
Stretching Exercises/Cognitive Training
Active Comparator
Intervention: Cognitive Training (Behavioral)
Outcomes
Primary Outcomes
Change from Baseline to 28 weeks in delayed recall of a word list
Time Frame: Baseline, 24 weeks, 28 weeks
Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task
Time Frame: Baseline, 24 weeks, 28 weeks
Secondary Outcomes
- Non-Cognitive Outcomes (Depression, Sleep, Quality of Life)(Baseline, Time 2, Time 3)
Investigators
J. Kaci Fairchild, PhD
Clinical Psychologist
Palo Alto Veterans Institute for Research
Study Sites (1)
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