Blastocystis subtypes in symptomatic and asymptomatic family members and pets and response to therapy.
Not Applicable
Completed
- Conditions
- Irritable bowel like gastrointestinal symptoms in patients positive for Blastocystis carriage in their stool.Response of symptomatic patients positive for Blastocystis to 14 days of therapy with metronidazole 400 mg three times daily or sulfamethoxazole/trimethoprim 160mg/800mg twice daily.Specific subtypes of Blastocystis found in symptomatic patients compared to asymptomatic human and animal household members.Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12610001066077
- Lead Sponsor
- Dr Rebecca Traub
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Chronic gastrointestinal symptoms
Exclusion Criteria
Other documented cause of gastrointestinal symptoms other than Blastocystis carriage
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence or absence of Blastocystis in stool samples before and after antibiotic therapy as assessed by fresh faecal smears, faecal culture and PCR analysis of both faecal specimens and faecal cultures.[Sample time points were baseline (0-2 weeks before therapy), Day 15, 28 and 56.]
- Secondary Outcome Measures
Name Time Method To assess how many asymptomatic human and animal household contacts of symptomatic patients were also positive for Blastocystis in their stool and to assess if there was any difference in Blastocystis subtypes between symptomatic and asymptomatic carriers.[Faecal samples were assessed at Day 15 in these groups with fresh faecal smears, faecal cultures and PCR analysis of both faeces and faecal cultures.]