临床试验/NCT03387345

NCT03387345已完成不适用

β-glucan Rich Barley and Rice Mixes and Post-prandial Glycemia - a Dose Response Study

Arizona State University2 个研究点分布在 1 个国家目标入组 39 人开始时间: 2017年2月13日最近更新: 2018年1月2日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: Arizona State University
入组人数: 39
试验地点: 2
主要终点: Post-prandial glycemia

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this research was to investigate 5 different formulations of whole grain barley and refined white rice against a control of white bread on post-prandial glycemic response, as well as self-reported hunger/satiety in a randomized cross-over trial.

详细描述

Beta-glucan-rich barley has been shown to improve glycemic response, reduce hunger and increase satiety. Nutrient-dense grain mixtures that include a new cultivar of barley (Sustagrain, Ardent Mills, LLC) with exceptionally high dietary fiber content may help individuals meet their dietary fiber needs while minimizing the rapid increase in blood glucose following the consumption of a refined grain product. The primary objective of this study was to compare the effects of five different test meals containing varying amounts of whole-grain barley and refined white rice to white bread on post-prandial blood glucose concentrations. A secondary aim was to evaluate changes in self-reported hunger and satiety following the consumption of each treatment. This study was a single-site, blinded, randomized crossover trial among 24 healthy adults. Each participant consumed the following treatments: 100% Sustagrain barley flakes, 100% Sustagrain steel cut barley , an 80/20 rice-steel cut Sustagrain barley mix, a 50/50 rice-steel cut Sustagrain barley mix, 100% rice, and white bread.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Prevention
盲法: None

入排标准

年龄范围: 18 Years 至 50 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Healthy, English speaking adults;
•BMI between 18 and 30 kg/m2

排除标准

•History of GI malabsorption diseases, food allergy or intolerance to gluten;
•Prediabetes, and/or diabetes, and/or treatment with diabetic medications for any reason;
•Hypertension, hypothyroidism and other chronic disease that affects nutrient metabolism;
•Any women pregnant or lactating, or expecting to become pregnant during the study;
•Individuals with a history of bleeding disorders

研究组 & 干预措施

bread-50/50-steelcut-80/20-flake-rice

Experimental

25 g of available carbohydrate was delivered to participants via (1) white bread, followed by (2) 50/50 rice-barley mix, followed by (3) 100% steel cut barley, followed by (4) 80/20 rice-barley mix, followed by (5) 100% barley flakes, followed by (6) 100% rice

干预措施: 100% steel cut barley (Other)

bread-50/50-steelcut-80/20-flake-rice

Experimental

干预措施: 100% barley flakes (Other)

bread-50/50-steelcut-80/20-flake-rice

Experimental

干预措施: 50/50 rice-barley mix (Other)

bread-50/50-steelcut-80/20-flake-rice

Experimental

干预措施: 80/20 rice-barley mix (Other)

bread-50/50-steelcut-80/20-flake-rice

Experimental

干预措施: 100% rice (Other)

50/50-steelcut-80/20-flake-rice-bread

Experimental

25 g of available carbohydrate was delivered to participants via (1) 50/50 rice-barley mix, followed by (2) 100% steel cut barley, followed by (3) 80/20 rice-barley mix, followed by (4) 100% barley flakes, followed by (5) 100% rice, followed by (6) white bread

干预措施: 50/50 rice-barley mix (Other)

bread-50/50-steelcut-80/20-flake-rice

Experimental

干预措施: white bread (Other)

50/50-steelcut-80/20-flake-rice-bread

Experimental

干预措施: 100% steel cut barley (Other)

50/50-steelcut-80/20-flake-rice-bread

Experimental

干预措施: 100% barley flakes (Other)

50/50-steelcut-80/20-flake-rice-bread

Experimental

干预措施: 80/20 rice-barley mix (Other)

50/50-steelcut-80/20-flake-rice-bread

Experimental

干预措施: 100% rice (Other)

50/50-steelcut-80/20-flake-rice-bread

Experimental

干预措施: white bread (Other)

steelcut-80/20-flake-rice-bread-50/50

Experimental

25 g of available carbohydrate was delivered to participants via (1) 100% steel cut barley, followed by (2) 80/20 rice-barley mix, followed by (3) 100% barley flakes, followed by (4) 100% rice, followed by (5) white bread, followed by (6) 50/50 rice-barley mix

干预措施: 100% steel cut barley (Other)

steelcut-80/20-flake-rice-bread-50/50

Experimental

干预措施: 100% barley flakes (Other)

steelcut-80/20-flake-rice-bread-50/50

Experimental

干预措施: 50/50 rice-barley mix (Other)

steelcut-80/20-flake-rice-bread-50/50

Experimental

干预措施: 80/20 rice-barley mix (Other)

steelcut-80/20-flake-rice-bread-50/50

Experimental

干预措施: 100% rice (Other)

steelcut-80/20-flake-rice-bread-50/50

Experimental

干预措施: white bread (Other)

80/20-flake-rice-bread-50/50-steelcut

Experimental

25 g of available carbohydrate was delivered to participants via (1) 80/20 rice-barley mix, followed by (2) 100% barley flakes, followed by (3) 100% rice, followed by (4) white bread, followed by (5) 50/50 rice-barley mix, followed by (6) 100% steel cut barley

干预措施: 100% steel cut barley (Other)

80/20-flake-rice-bread-50/50-steelcut

Experimental

干预措施: 100% barley flakes (Other)

80/20-flake-rice-bread-50/50-steelcut

Experimental

干预措施: 50/50 rice-barley mix (Other)

80/20-flake-rice-bread-50/50-steelcut

Experimental

干预措施: 80/20 rice-barley mix (Other)

80/20-flake-rice-bread-50/50-steelcut

Experimental

干预措施: 100% rice (Other)

80/20-flake-rice-bread-50/50-steelcut

Experimental

干预措施: white bread (Other)

flake-rice-bread-50/50-steelcut-80/20

Experimental

25 g of available carbohydrate was delivered to participants via (1) 100% barley flakes, followed by (2) 100% rice, followed by (3) white bread, followed by (4) 50/50 rice-barley mix, followed by (5) 100% steel cut barley, followed by (6) 80/20 rice-barley mix

干预措施: 100% steel cut barley (Other)

flake-rice-bread-50/50-steelcut-80/20

Experimental

干预措施: 100% barley flakes (Other)

flake-rice-bread-50/50-steelcut-80/20

Experimental

干预措施: 50/50 rice-barley mix (Other)

flake-rice-bread-50/50-steelcut-80/20

Experimental

干预措施: 80/20 rice-barley mix (Other)

flake-rice-bread-50/50-steelcut-80/20

Experimental

干预措施: 100% rice (Other)

flake-rice-bread-50/50-steelcut-80/20

Experimental

干预措施: white bread (Other)

rice-bread-50/50-steelcut-80/20-flake

Experimental

25 g of available carbohydrate was delivered to participants via (1) 100% rice, followed by (2) white bread, followed by (3) 50/50 rice-barley mix, followed by (4) 100% steel cut barley, followed by (5) 80/20 rice-barley mix, followed by (6) 100% barley flakes

干预措施: 100% steel cut barley (Other)

rice-bread-50/50-steelcut-80/20-flake

Experimental

干预措施: 100% barley flakes (Other)

rice-bread-50/50-steelcut-80/20-flake

Experimental

干预措施: 50/50 rice-barley mix (Other)

rice-bread-50/50-steelcut-80/20-flake

Experimental

干预措施: 80/20 rice-barley mix (Other)

rice-bread-50/50-steelcut-80/20-flake

Experimental

干预措施: 100% rice (Other)

rice-bread-50/50-steelcut-80/20-flake

Experimental

干预措施: white bread (Other)

结局指标

主要结局

Post-prandial glycemia

时间窗: 0 min, 15 min, 30 min, 45min , 60 min, 90 min, 120 min

Incremental area under the curve(iAUC) for plasma glucose concentrations were measured at 0, 15, 30, 45, 60, 90 and 120 min using the trapezoidal method to evaluate the glycemic response to each grain treatment.

次要结局

Self-reported hunger(0 min, 15 min, 30 min, 60 min, 90 min, 120 min)
Self-reported satiety(0 min, 15 min, 30 min, 60 min, 90 min, 120 min)
Self-reported fullness(0 min, 15 min, 30 min, 60 min, 90 min, 120 min)
Self-reported prospective food consumption(0 min, 15 min, 30 min, 60 min, 90 min, 120 min)

研究者

发起方

Arizona State University

申办方类型

Other

责任方

Principal Investigator

主要研究者

Corrie Whisner

Assistant Professor

Arizona State University

研究点 (2)

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