Fish oil treatment for depression in cardiovascular disease

Not Applicable

Recruiting

• Conditions: Depression; Cardiovascular Disease; Mental Health - Depression; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12608000598381
• Lead Sponsor: Dr Geoffrey Schrader

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-12-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

(a)angiographically-documented coronary artery disease, defined as >50% stenosis in an epicardial coronary artery on selective coronary angiography.
(b)Co-morbid depression as determined by a score of greater than or equal to 16 on the Center for Epidemiologic Studies – Depression (CES-D) scale
(c)able to complete questionnaires in written English.

Exclusion Criteria

(a) more than one fish meals per week
(b) currently using fish oil supplementation (>300mg eicosapentaenoic acid (EPA)+ docosahexaenoic acid (DHA)/day)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression as measured by the Hamilton Rating Scale For Depression[Baseline, 3 months, 6 months]

Secondary Outcome Measures

Name	Time	Method
Quality of Life as measured by the Short Form (SF)-36[Baseline, 3 months, 6 months];Angina frequency as measured by the Seattle Angina Questionnaire[Baseline, 3 months, 6 months];Degree of change in vasodilator function assessed by flow mediated dilatation (FMD) in the brachial artery[Baseline, 6 months];Changes in cerebral blood flow measured by transcranial Doppler ultrasound[Baseline, 6 months]