Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

Completed

• Conditions: Enamel Erosion
• Interventions: Drug: Positive control dentifrice; Drug: Negative control dentifrice; Drug: Stannous fluoride dentifrice

• Registration Number: NCT04006470
• Lead Sponsor: Procter and Gamble

Brief Summary

The aim of this 5 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices to assess enamel erosion protection in-situ using surface profilometry.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-08
• Primary Completion: 2018-11-30
• Study Completion: 2018-11-30
• Status Verified: 2019-07
• Study First Submitted: 2019-07-01
• Study First Submitted QC: 2019-07-01
• Last Update Submitted: 2019-07-01
• Study First Posted: 2019-07-05
• Last Update Posted: 2019-07-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 172

Inclusion Criteria

• healthy subjects

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Positive control dentifrice	Positive control dentifrice	Twice daily use
Negative control dentifrice	Negative control dentifrice	Twice daily use
Stannous Fluoride Dentifrice	Stannous fluoride dentifrice	Twice daily use

Primary Outcome Measures

Name	Time	Method
Change from Baseline Surface profilometry	10 days	Enamel samples will be measured via profilometry after 10 days of study use.

Trial Locations

Locations (1)

Multiple P&G Investigation Clinical Sites; 🇺🇸 Cincinnati, Ohio, United States