A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2)
- Conditions
- Advanced Non-small Cell Lung CancerHER2 Mutation
- Interventions
- Registration Number
- NCT06452277
- Lead Sponsor
- Bayer
- Brief Summary
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations.
Advanced NSCLC is a group of lung cancers that have spread to nearby tissues or to other parts of the body or that are unlikely to be cured or controlled with currently available treatments. HER2 is a protein that helps cells to grow and divide. A damage (also called mutation) to the building plans (genes) for this protein in cancer cells leads to a production of abnormal HER2 and therefore abnormal cell growth and division.
The study treatment, BAY 2927088, is expected to block the mutated HER2 protein which may stop the spread of NSCLC.
The main purpose of this study is to learn how well BAY 2927088 works and how safe it is compared with standard treatment, in participants who have advanced NSCLC with specific genetic changes called HER2 mutations.
The study participants will receive one of the study treatments:
* BAY 2927088 twice every day as a tablet by mouth, or
* Standard treatment in cycles of 21 days via infusion ("drip") into the vein. The treatment will continue for as long as participants benefit from it without any severe side effects or until they or their doctor decide to stop the treatment.
During the study, the doctors and their study team will:
* take imaging scans, including CT, PET, MRI, and X-rays, of different parts of the body to study the spread of cancer
* check the overall health of the participants by performing tests such as blood and urine tests, and checking
* heart health using an electrocardiogram (ECG)
* perform pregnancy tests for women
* ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 278
- Participant must be ≥18 years of age or over the legal age of consent in countries where that is greater than 18 years at the time of signing the informed consent.
- Documented histologically or cytologically confirmed locally advanced non-squamous NSCLC, not suitable for definitive therapy or metastatic non-squamous NSCLC at screening (small cell or mixed histologies are excluded) (Stage III-IV NSCLC).
- Documented activating HER2 mutation in the tyrosine kinase domain (TKD) assessed by tissue molecular test in a CLIA-certified (US sites) or an equally accredited (outside of the US) local laboratory. However, participants may be included at the discretion of the investigator if the laboratory performing the assay is not CLIA or similar certified but the laboratory is locally accredited.
- No prior systemic therapy for locally advanced or metastatic disease. No prior treatment with a HER2 ex20ins-targeted therapy (e.g. poziotinib, trastuzumab deruxtecan). Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 12 months prior to the start of screening.
- Eligible to receive treatment with the selected platinum-based doublet-chemotherapy (i.e. cisplatin/pemetrexed or carboplatin/pemetrexed) and pembrolizumab in accordance with the SmPC/Product Information.
-
Known history of prior malignancy except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for five years since initiation of that therapy. Exception: the following cancer types are acceptable within five years if curatively treated or under surveillance:
- a. in situ cancers of cervix, breast, or skin,
- b. superficial bladder cancer (Ta, Tis and T1),
- c. limited-stage prostate cancer,
- d. basal or squamous cancers of the skin.
-
Tumors with targetable alterations with approved available therapy, with the exception of HER2 mutation in the TKD.
-
Inability to discontinue treatment with chronic systemic corticosteroids. Participants who require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study. Replacement therapy (e.g., physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is acceptable, provided that the dose is stable for >4 weeks prior to planned start of study intervention.
-
Pre-existing peripheral neuropathy that is Grade ≥2 by CTCAE (v5.0).
-
History of severe hypersensitivity reaction to treatment with a monoclonal antibody.
-
Prior radiotherapy outside of the brain within 21 days of planned start of study intervention. Participants must have recovered from all radiation-related toxicities and not require corticosteroids.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Standard of care (SoC) Pembrolizumab Participants will receive SoC (pembrolizumab in combination with platinum-based chemotherapy, in 21-day cycles per the approved labels) until disease progression per RECIST v1.1, unacceptable toxicity, or until any other withdrawal criteria. Standard of care (SoC) Cisplatin Participants will receive SoC (pembrolizumab in combination with platinum-based chemotherapy, in 21-day cycles per the approved labels) until disease progression per RECIST v1.1, unacceptable toxicity, or until any other withdrawal criteria. Standard of care (SoC) Carboplatin Participants will receive SoC (pembrolizumab in combination with platinum-based chemotherapy, in 21-day cycles per the approved labels) until disease progression per RECIST v1.1, unacceptable toxicity, or until any other withdrawal criteria. Standard of care (SoC) Pemetrexed Participants will receive SoC (pembrolizumab in combination with platinum-based chemotherapy, in 21-day cycles per the approved labels) until disease progression per RECIST v1.1, unacceptable toxicity, or until any other withdrawal criteria. BAY2927088 BAY2927088 Participants will receive BAY2927088 20 mg BID until disease progression per RECIST v1.1, unacceptable toxicity, or until any other withdrawal criteria.
- Primary Outcome Measures
Name Time Method Progression free survival (PFS) per RECIST 1.1 as assessed by BICR Up to approximately 2 years RECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BICR = blinded independent central review (BICR)
- Secondary Outcome Measures
Name Time Method Overall survival (OS) Up to approximately 4 years. Objective response rate (ORR) per RECIST 1.1 as assessed by BICR Up to approximately 4 years RECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BICR = blinded independent central review (BICR)
Progression free survival (PFS) per RECIST 1.1 as assessed by the investigator Up to approximately 4 years RECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1
Disease control rate (DCR) per RECIST 1.1 as assessed by the investigator Up to approximately 4 years RECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1
Objective Response Rate (ORR) as assessed by the investigator Up to approximately 4 years Disease control rate (DCR) per RECIST 1.1 as assessed by BICR Up to approximately 4 years RECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BICR = blinded independent central review (BICR)
Duration of response (DOR) as assessed by BICR Up to approximately 4 years BICR = blinded independent central review (BICR)
Adverse events per CTCAE v 5.0 (eg. TEAEs, TESAEs) categorized by severity Up to approximately 4 years CTCAE = common terminology criteria for adverse events; TEAE = treatment-emergent adverse event; TESAE = treatment-emergent serious adverse event
Duration of response (DOR) as assessed by the investigator Up to approximately 4 years Change from baseline in NSCLC-SAQ total score Up to approximately 4 years NSCLC-SAQ = Non-small cell lung cancer Symptom Assessment Questionnaire
Change from baseline in NSCLC-SAQ individual domain scores Up to approximately 4 years NSCLC-SAQ = Non-small cell lung cancer Symptom Assessment Questionnaire; Domains: cough, pain, dyspnea, fatigue, appetite
Time to deterioration in NSCLC-SAQ total score Up to approximately 4 years NSCLC-SAQ = Non-small cell lung cancer Symptom Assessment Questionnaire
Time to deterioration in NSCLC-SAQ individual domain scores Up to approximately 4 years NSCLC-SAQ = Non-small cell lung cancer Symptom Assessment Questionnaire; Domains: cough, pain, dyspnea, fatigue, appetite
Time to deterioration in EORTC QLQ-C30 physical functioning domain score Up to approximately 4 years EORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30
Change from baseline in EORTC QLQ-C30 physical functioning domain score Up to approximately 4 years EORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; QoL: quality of life
Change from baseline in EORTC QLQ-C30 global health status/QoL Up to approximately 4 years EORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; QoL: quality of life
Trial Locations
- Locations (267)
Memorial Cancer Institute at Miramar
🇺🇸Miramar, Florida, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
MHAT Sveta Marina EAD
🇧🇬Varna, Bulgaria
Docrates Mehiläinen Syöpäsairaala
🇫🇮Helsinki, Finland
Institut Bergonie - Unicancer Nouvelle Aquitaine
🇫🇷Bordeaux, France
Hopital Foch - Oncologie digestive et thoracique
🇫🇷Suresnes, France
Gustave Roussy - Departement Oncologie-Radiotherapie
🇫🇷Villejuif Cedex, France
Centre Hospitalier Intercommunal Creteil - Service de pneumologie
🇫🇷Créteil, France
Institut de Cancerologie Ouest - Saint-Herblain
🇫🇷Saint-Herblain, France
Centro Hospitalar e Universitario de Coimbra EPE (CHUC)
🇵🇹Coimbra, Portugal
Patty & George Hoag Cancer Center
🇺🇸Newport Beach, California, United States
Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia
🇲🇽Nuevo León, Mexico
Rivne regional antitumor hospital
🇺🇦Rivne, Ukraine
UC San Diego Health - Moores Cancer Center
🇺🇸San Diego, California, United States
University of California San Francisco (UCSF) - Thoracic Surgery and Oncology Clinic
🇺🇸San Francisco, California, United States
Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit
🇬🇧Cardiff, United Kingdom
Hospital Ramón y Cajal | Oncología
🇪🇸Madrid, Spain
Fundacion Jimenez Diaz (Clinica de la Concepcion)
🇪🇸Madrid, Spain
Complejo Hospitalario de Navarra
🇪🇸Pamplona, Spain
Medical Center LLC "Verum Expert Clinic"
🇺🇦Kyiv, Ukraine
Brampton Civic Hospital - Oncology
🇨🇦Brampton, Ontario, Canada
The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC)
🇦🇺Garran, Australia
ASST Sette Laghi_Ospedale Macchi - Oncologia
🇮🇹Varese, Italy
Austin Hospital - Olivia Newton John Cancer Research Institute
🇦🇺Heidelberg, Australia
Volyn Regional Oncology Center
🇺🇦Lutsk, Ukraine
Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III
🇦🇹Salzburg, Austria
Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde
🇦🇹Salzburg, Austria
Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia
🇮🇹Verona, Italy
Hospital Clinic de Barcelona (Hospital Clinic i Provincial)
🇪🇸Barcelona, Spain
Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie
🇦🇹Wien, Austria
Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik
🇦🇹Wien, Austria
University of California Los Angeles (UCLA) - Cancer Care - Santa Monica
🇺🇸Santa Monica, California, United States
The Oncology Institute of Hope and Innovation
🇺🇸Whittier, California, United States
AdventHealth Cancer Institute
🇺🇸Orlando, Florida, United States
Moffitt Cancer Center
🇺🇸Tampa, Florida, United States
University of Illinois at Chicago
🇺🇸Chicago, Illinois, United States
The U Chicago Medicine Comprehensive Cancer Center
🇺🇸Chicago, Illinois, United States
Specialized Hospital for Active Treatment of Oncology
🇧🇬Sofia, Bulgaria
University of Maryland
🇺🇸Baltimore, Maryland, United States
UMass Memorial Medical Center - University Campus
🇺🇸Worcester, Massachusetts, United States
Profound Research LLC
🇺🇸Farmington Hills, Michigan, United States
University of Minnesota Medical Center
🇺🇸Minneapolis, Minnesota, United States
Northwell Health Cancer Institute - R.J. Zuckerberg Cancer Center (Monter Cancer Center) - Center for Advanced Medicine Location
🇺🇸New Hyde Park, New York, United States
University of Cincinnati Medical Center
🇺🇸Cincinnati, Ohio, United States
Providence Cancer Institute - Franz Clinic
🇺🇸Portland, Oregon, United States
UT Southwestern
🇺🇸Dallas, Texas, United States
University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Fundación Cenit para la Investigación en Neurociencias
🇦🇷Caba, Ciudad Auton. De Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Buenos Aires, Argentina
Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC)
🇦🇷Buenos Aires, Argentina
Centro Médico Privado CEMAIC
🇦🇷Córdoba, Argentina
Instituto Argentino de Diagnostico y Tratamiento (IADT)
🇦🇷TBC, Argentina
Centro de Investigaciones Clínicas, Clínica Viedma
🇦🇷Viedma, Argentina
Blacktown Cancer & Haematology Centre
🇦🇺Blacktown, New South Wales, Australia
Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit
🇦🇺Concord, New South Wales, Australia
Calvary Mater Hospital Newcastle
🇦🇺Waratah, New South Wales, Australia
University of the Sunshine Coast
🇦🇺Buderim, Australia
UZ Leuven Gasthuisberg - Pneumology Department
🇧🇪Leuven, Vlaams-Brabant, Belgium
AZ Delta | Clinical Trial Center - Pneumology
🇧🇪Roeselare, West-Flanders, Belgium
Antwerp University Hospital | Oncology Department
🇧🇪Antwerpen, Belgium
Rede DoR Recife - PE
🇧🇷Recife, Pernambuco, Brazil
Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica
🇧🇷Natal, Rio Grande Do Norte, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centro de Pesquisa da Clínica de Oncologia Reichow
🇧🇷Blumenau, Santa Catarina, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos
🇧🇷Barretos, Sao Paulo, Brazil
Hospital de Base | Integrated Research Center
🇧🇷São José do Rio Preto, Sao Paulo, Brazil
NAIC - Instituto do Cancer
🇧🇷Bauru, Brazil
Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia
🇧🇷Brasilia, Brazil
Pronutrir Fortaleza - CE
🇧🇷Fortaleza, Brazil
Hospital Sirio Libanes
🇧🇷Sao Paulo, Brazil
A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante
🇧🇷Sao Paulo, Brazil
Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima
🇧🇷Sao Paulo, Brazil
MHAT Uni Hospital
🇧🇬Panagyurishte, Pazardzhik, Bulgaria
MHAT "Heart and brain" Pleven
🇧🇬Pleven, Bulgaria
Complex Oncology Center - Plovdiv EOOD
🇧🇬Plovdiv, Bulgaria
MHAT Park Hospital EOOD
🇧🇬Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment "Sveta Sofia"
🇧🇬Sofia, Bulgaria
MHAT Serdika
🇧🇬Sofia, Bulgaria
MHAT Sofiamed
🇧🇬Sofia, Bulgaria
Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology
🇨🇦Toronto, Ontario, Canada
Jewish General Hospital - Department of Pulmonary Oncology
🇨🇦Montreal, Quebec, Canada
BC Cancer - Vancouver
🇨🇦Vancouver, Canada
Beijing Cancer Hospital
🇨🇳Beijing, Beijing, China
Beijing Hospital
🇨🇳Beijing, Beijing, China
Fujian Cancer Hospital
🇨🇳Fuzhou, Fujian, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech
🇨🇳Wuhan, Hubei, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School
🇨🇳Nanjing, Jiangsu, China
Jilin Cancer Hospital
🇨🇳Changchun, Jilin, China
Shanghai Chest Hospital, Shanghai Jiaotong University
🇨🇳Shanghai, Shanghai, China
West China Hospital Sichuan University
🇨🇳Chengdu, Sichuan, China
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province
🇨🇳Taizhou, Zhejiang, China
Cancer Hospital, Chinese Academy of Medical Sciences
🇨🇳Beijing, China
The People's Liberation Army General Hospital (Beijing 301 Hospital)
🇨🇳Beijing, China
Beijing chest hospital, Capital Medical University
🇨🇳Beijing, China
University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital)
🇨🇳Chengdu, China
Guangzhou Medical University - The First Affiliated Hospital
🇨🇳Guangzhou, China
Shandong University - Shandong Cancer Hospital
🇨🇳Jinan, China
LinYi Cancer Hospital (Linyi Tumor Hospital)
🇨🇳Linyi, China
Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University
🇨🇳Nanjing, China
Guangxi Medical University (GXMU) - Affiliated Tumor Hospital
🇨🇳Nanning, China
Fudan University - Zhongshan Hospital
🇨🇳Shanghai, China
Xiamen University - The First Affiliated Hospital
🇨🇳Xiamen, China
Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie
🇨🇿Zlin, Zlinsky Kraj, Czechia
Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP)
🇨🇿Brno, Czechia
Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie
🇨🇿Nový Jicín, Czechia
Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy
🇨🇿Olomouc, Czechia
Vitkovicka nemocnice a.s.
🇨🇿Ostrava, Czechia
Aalborg University hospital - oncology department
🇩🇰Aalborg, Denmark
Aarhus Universitetshospital
🇩🇰Aarhus N, Denmark
Rigshospitalet - Kræftbehandling
🇩🇰Copenhagen OE, Denmark
Regionshospitalet Gødstrup - Medicinsk afdeling
🇩🇰Herning, Denmark
Odense University Hospital - Oncology Department
🇩🇰Odense C, Denmark
Turun yliopistollinen keskussairaala
🇫🇮Turku, Finland
Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie
🇫🇷Brest, France
Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire
🇫🇷Lille, France
Centre Hospitalier Michallon Grenoble - Service pneumologie
🇫🇷La Tronche, France
hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique
🇫🇷Pierre Bénite, France
Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique
🇫🇷Limoges, France
hopital Arnaud de Villeneuve CHU Montpellier - service oncologie thoracique
🇫🇷Montpellier, France
hopital Emile Muller - Service Pneumologie
🇫🇷Mulhouse, France
hopital cochin APHP - service de pneumologie
🇫🇷Paris, France
Institut Curie - Paris - Oncologie medicale
🇫🇷Paris, France
CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie
🇫🇷Rouen, France
Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie
🇩🇪Giessen, Hessen, Germany
Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik
🇩🇪Köln, Nordrhein-Westfalen, Germany
Universitaetsklinikum Essen - Innere Klinik (Tumorforschung)
🇩🇪Essen, North Rhine-Westphalia, Germany
Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie
🇩🇪Berlin, Germany
Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie
🇩🇪Frankfurt, Germany
Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin
🇩🇪Hemer, Germany
Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde)
🇩🇪Nürnberg, Germany
Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin
🇩🇪Stuttgart, Germany
University of Athens Medical School-Sotiria General Hospital - 3rd Dept of Medicine & Medical Oncology
🇬🇷Athens, Greece
University of Athens Medical School- Alexandra General Hospital of Athens
🇬🇷Athens, Greece
University General Hospital ATTIKON, Department of Internal Medicine IV
🇬🇷Chaidari, Greece
University General Hospital of Athens "ATTIKON"
🇬🇷Chaidari, Greece
University General Hospital of Larissa
🇬🇷Larissa, Greece
Metropolitan Hospital- 4th Oncology Clinic
🇬🇷Piraeus, Greece
Bioclinic Thessaloniki
🇬🇷Thessaloniki, Greece
PAPANIKOLAOU General Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
Prince of Wales Hospital
🇭🇰Hong Kong, Hong Kong
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
Queen Elizabeth Hospital Hong Kong
🇭🇰Hong Kong, Hong Kong
Hong Kong United Oncology Centre
🇭🇰Kowloon, Hong Kong
Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály
🇭🇺Budapest, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
🇭🇺Tatabanya, Hungary
Assuta Ashdod Public Hospital (R.A)
🇮🇱Ashdod, Israel
Soroka Medical Center- Legacy Heritage Cancer Center
🇮🇱Be'er Sheva, Israel
Shaare Zedek Medical Center (SZMC)
🇮🇱Jerusalem, Israel
Tel-Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica
🇮🇹Avellino, Campania, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica
🇮🇹Bologna, Emilia-Romagna, Italy
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica
🇮🇹Meldola, Emilia-Romagna, Italy
Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati
🇮🇹Aviano, Friuli-Venezia Giulia, Italy
I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2
🇮🇹Roma, Lazio, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare
🇮🇹Roma, Lazio, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1
🇮🇹Milano, Lombardia, Italy
Istituto Europeo di Oncologia s.r.l - Oncologia Toracica
🇮🇹Milano, Lombardia, Italy
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia
🇮🇹Rozzano, Lombardia, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica
🇮🇹Orbassano, Piemonte, Italy
Istituto Oncologico Veneto_Padova - UOC Oncologia 2
🇮🇹Padova, Veneto, Italy
Careggi University Hospital - Oncologia Clinica
🇮🇹Firenze, Italy
Ospedale Vito Fazzi Lecce - Oncologia
🇮🇹Lecce, Italy
Ospedale San Raffaele s.r.l. - Oncologia Medica
🇮🇹Milano, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica
🇮🇹Palermo, Italy
National Hospital Organization Nagoya Medical Center
🇯🇵Nagoya, Aichi, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa, Chiba, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
National Hospital Organization Himeji Medical Center
🇯🇵Himeji, Hyogo, Japan
Kobe University Hospital
🇯🇵Kobe, Hyogo, Japan
Kitasato University Hospital
🇯🇵Sagamihara, Kanagawa, Japan
Sendai Kousei Hospital
🇯🇵Sendai, Miyagi, Japan
Kansai Medical University Hospital
🇯🇵Hirakata, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama, Osaka, Japan
Saitama Cancer Center
🇯🇵Kitaadachi-gun, Saitama, Japan
Nippon Medical School - Nippon Medical School Hospital - Cancer Center
🇯🇵Bunkyo-ku, Tokyo, Japan
Tottori University Hospital
🇯🇵Yonago, Tottori, Japan
National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital)
🇯🇵Ube, Yamaguchi, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata, Japan
Osaka International Cancer Institute
🇯🇵Osaka, Japan
Chungbuk National University Hospital
🇰🇷Cheongju-si, Chungcheongbugdo, Korea, Republic of
Gyeongsang National University Hospital
🇰🇷Jinju-si, Gyeongsangnam-do, Korea, Republic of
Pusan National University Yangsan Hospital
🇰🇷Yangsan-si, Gyeongsangnamdo, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷Hwasun Gun, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Sunway Medical Centre
🇲🇾Subang Jaya, Selangor, Malaysia
University Hospital Kebangsaan Malaysia
🇲🇾Cheras, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Sunway Medical Centre Penang
🇲🇾Perai, Malaysia
Beacon Hospital
🇲🇾Petaling Jaya, Selangor, Malaysia
Columbia Asia Hospital Bukit Rimau
🇲🇾Shah Alam, Malaysia
Instituto Nacional de Cancerología
🇲🇽México, Distrito Federal, Mexico
Oncare Viaducto Nápoles
🇲🇽Cdmx, Mexico
Oncología Integral Satélite
🇲🇽Naucalpan, Mexico
Clinica Integral Internacional de Oncologia S. de R.L. de C.V.
🇲🇽Puebla, Mexico
ONCARE Treatment Center
🇲🇽San Pedro Garza García, Mexico
Nederlands Kanker Instituut
🇳🇱Amsterdam, Netherlands
Radboud University Medical Center | Afdeling Interne Geneeskunde
🇳🇱Nijmegen, Netherlands
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej
🇵🇱Warsaw, Mazowieckie, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
🇵🇱Bialystok, Poland
Swietokrzyskie Centrum Onkologii
🇵🇱Kielce, Poland
SP ZOZ USK im. WAM UM w Lodzi - Centralny Szpital Weteranow
🇵🇱Lodz, Poland
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku
🇵🇱Otwock, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii
🇵🇱Poznan, Poland
Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii
🇵🇱Wroclaw, Poland
Hospital Pedro Hispano | Clinical Research Center
🇵🇹Matosinhos, Porto, Portugal
Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica
🇵🇹Lisboa, Portugal
CHULN - Hospital Pulido Valente
🇵🇹Lisboa, Portugal
IPO Porto
🇵🇹Porto, Portugal
Radiotherapy Center Cluj SRL
🇷🇴Flore?ti, Comuna Floresti, Romania
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II
🇷🇴Bucuresti, Romania
Spitalul Clinic Coltea
🇷🇴Bucuresti, Romania
Hospital General Universitario Gregorio Maranon | Oncologia
🇪🇸Madrid, Spain
CardioMed S.R.L.
🇷🇴Cluj-Napoca, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta
🇷🇴Cluj-Napoca, Romania
Sc Oncolab Srl
🇷🇴Craiova, Romania
Centrul de Oncologie Sfantul Nectarie
🇷🇴Craiova, Romania
S.C Ovidius Clinical Hospital SRL - Oncology Department
🇷🇴Ovidiu, Romania
Oncocenter
🇷🇴Timisoara, Romania
Raffles Cancer Centre
🇸🇬Singapore, Singapore
OncoCare Cancer Centre | Gleneagles Medical Centre
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Curie Oncology | Farrer
🇸🇬Singapore, Singapore
POKO Poprad s.r.o.
🇸🇰Poprad, Slovakia
Fakultna nemocnica Trnava
🇸🇰Trnava, Slovakia
Hospital Universitario Clinica Puerta de Hierro
🇪🇸Majadahonda, Madrid, Spain
Complejo Hospitalario Universitario A Coruna (CHUAC)
🇪🇸A Coruna, Spain
Institut Catala d'Oncologia (ICO) - Hospital Universitari Germans Trias i Pujol (HUGTP) Location
🇪🇸Badalona, Spain
Hospital Quiron Dexeus
🇪🇸Barcelona, Spain
Ciutat Sanitaria i Universitaria de la Vall d'Hebron
🇪🇸Barcelona, Spain
Fundacion Instituto Valenciano de Oncologia (IVO
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe | Oncologia
🇪🇸Valencia, Spain
Skåne University Hospital
🇸🇪Lund, Sweden
Norrland University Hospital - Cancercentrum
🇸🇪Umeå, Sweden
Kantonsspital Baden
🇨🇭Baden, Aargau, Switzerland
HFR Freiburg - Kantonsspital
🇨🇭Fribourg, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung City, Kaohsiung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, TNN, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Chi-Mei Medical Center, Liouyine
🇨🇳Tainan, Taiwan
National Taiwan University Hospital (NTUH) - Cancer Research Center
🇨🇳Taipei, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Ankara Bilkent Sehir Hastanesi
🇹🇷Bilkent Ankara, Turkey
Marmara University Hospital
🇹🇷Istanbul, Turkey
Ege Universitesi Tip Fakultesi
🇹🇷Izmir, Turkey
Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi
🇹🇷Kadikoy, Turkey
I.A.Ü. VM Medical Park Florya Hastanesi
🇹🇷Kucukcekmece, Turkey
Sakarya Universitesi Egitim ve Arastirma Hastanesi
🇹🇷Sakarya, Turkey
Ankara Etlik Sehir Hastanesi
🇹🇷Yenimahalle, Turkey
Adana Sehir Egitim ve Arastirma Hastanesi
🇹🇷Yüregir, Turkey
LLC "RDP Ukraine" - Medical Department
🇺🇦Dnipro, Ukraine
Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center
🇺🇦Kropyvnytskyi, Ukraine
Kyiv City Clinical Oncology Center - Department of Chemotherapy #1
🇺🇦Kyiv, Ukraine
Limited Liability Company "MedOffice Group Medical Center"
🇺🇦Kyiv, Ukraine
MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department
🇺🇦Uzhhorod, Ukraine
Torbay Hospital
🇬🇧Torquay, Devon, United Kingdom
Belfast City Hospital
🇬🇧Belfast, North Ireland, United Kingdom
Royal Surrey County Hospital
🇬🇧Guildford, Surrey, United Kingdom