Study of Motor Control Mechanisms in DBS-implanted Parkinson's Disease Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- Corticospinal excitability
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
Akinesia is one of the most prominent symptom in Parkinson's Disease (PD) patients. It typically consists in a inability to initiate voluntary movement, and it affects patients' quality of life. This study aims at exploring the influence of Deep Brain Stimulation (DBS) in the quality of motor control, and particularly of voluntary movement initiation, and its neural correlates. They will be evaluated using behavioral and motor tasks together with Transcranial Magnetic Stimulation (TMS) and electrophysiology (EMG and EEG).
Investigators
Eligibility Criteria
Inclusion Criteria
- •PD patients that are monitored for the tuning of their DBS stimulator by Grenoble's Hospital.
- •PD patients that are hospitalized for the tuning routine 12 months after the surgical implantation.
- •Good tolerance following temporary stops of the DBS stimulator
- •Affiliated to a social security system
- •Mental abilities sufficient for performing the behavioral tasks (MMSE score \>= 24, tested less than 6 months ago)
Exclusion Criteria
- •Patients that are concerned by articles L1121-5, L1121-6, L1121-7 and L1121-8 of French Code de la Santé Publique,
- •History of psychiatric or neurological illness other than PD
- •Patients that are currently excluded from an other clinical trial
- •Contraindications for TMS practice
- •Inability to stay seated without pain for two hours
- •Pregnancy
Outcomes
Primary Outcomes
Corticospinal excitability
Time Frame: 60 minutes
Corticospinal excitability is measured trough the amplitudes of TMS-evoked motor potentials recorded on the EMG at rest, and during the behavioral and motor tasks, in the two experimental conditions (DBS stimulator ON and OFF).
Secondary Outcomes
- Cortical excitability(60 minutes)
- Cortico-subcortical connectivity(20 minutes)
- Correlation between behavioral and neural responses(60 minutes)