Cycling and Treadmill With Dual Task for Parkinson's Disease Improvement
- Conditions
- Parkinson Disease(PD)
- Interventions
- Other: Cognitive cycling trainingOther: Cognitive treadmill training
- Registration Number
- NCT06355947
- Lead Sponsor
- Chang Gung University
- Brief Summary
Motor impairment in lower extremities is common in individuals with Parkinson disease (PD). Development sensitive test for early motor deviations is important. Conventional walking test cannot induce the PD related motor impairments, such as freezing of gait. Therefore, finding a safe substitute test to induce PD related motor impairments is important.
Studies showed that working memory related dual task walking was a sensitive test for PD. However, the optimal cognitive test needs to be clarified. Studies also showed that the neuromuscular control mechanism of leg movements during cycling were similar to those during walking. Therefore, dual task cycling test is potential to be a safe and sensitive testing model.
Studies showed that exercise could improve cognitive function and induce brain plasticity. Dual task exercise training was shown to be more effective than single task exercise training for older people to prevent fall. Whether the added cognitive task could improve to detriment brain plasticity in PD should be investigated. Transcranial magnetic stimulation can evaluate the motor cortex plasticity on-invasively and can evaluate the exercise induced brain plasticity.
The purpose of this three-year project is to develop PD-sensitive. The purposes of the first year are to translate the dual task walking test to dual task cycling test, and to establish the reliability of the dual task cycling test.
The purposes of the second year are to compare the motor cortex plasticity induced by single task cycling versus dual task cycling and to compare the difference response between PD and healthy control people.
The purpose of the third year is to evaluate the effect of 8 week long term cycling training or treadmill training of individuals with PD on motor cortex plasticity, dual task performance, and ambulation ability.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Clinical diagnosis of Parkinson disease.
- Musculoskeletal injuries on legs
- Osteoporosis.
- Any peripheral or central nervous system injury or disease patients.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Stage 3:PD cycling training group Cognitive cycling training Cycling training conducted with cognitive tasks Stage 3: PD treadmill training group Cognitive treadmill training Treadmill training conducted with cognitive tasks
- Primary Outcome Measures
Name Time Method Task Accuracy Baseline, 4 weeks and 8 weeks. The percentage of correct responses or actions made by participants in response to walking or cycling tasks.
Reaction Time Baseline, 4 weeks and 8 weeks. The duration between the onset of task start time and the participant's response to it, typically expressed in second (s).
Balance Performance Baseline, 4 weeks and 8 weeks Measured by the duration the stance can be maintained, typically expressed second.
Step Length Baseline, 4 weeks and 8 weeks The linear distance between the two ankles, typically expressed in centimeters(cm).
Power Spectral Density (PSD) Baseline, 4 weeks and 8 weeks. Quantifies the power of EEG signals within specific frequency bands (e.g., delta, theta, alpha, beta, and gamma) over a period.
Walking Speed Baseline, 4 weeks and 8 weeks The time taken by participants to walk a standardized distance, typically expressed in centimeters per second (cm/s).
Step Time Baseline, 4 weeks and 8 weeks The duration taken for one complete step, measuring from foot-off of one foot to the next foot-off of the same foot, usually expressed in seconds.
- Secondary Outcome Measures
Name Time Method Swing Time Baseline, 4 weeks and 8 weeks The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds.
Single Support Time Baseline, 4 weeks and 8 weeks The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle.
Heart rate Baseline The number of heartbeats per minute on resting, walking or cycling tasks.
Stance Time Baseline, 4 weeks and 8 weeks The portion of the gait cycle when the foot is in contact with the ground, supporting body weight. It's typically expressed as a percentage of the total gait cycle or in seconds
Double Support Time Baseline, 4 weeks and 8 weeks The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds.
Cadence Baseline, 4 weeks and 8 weeks The number of steps an individual takes per minute, providing an overview of gait speed and rhythm, , expressed as steps per minute.
Trial Locations
- Locations (1)
Chang Gung University
🇨🇳Taoyuan, Taiwan