Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- University Hospital, Bordeaux
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Cortico-subcortical electrophysiological coherence
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network with a wide frequency range. In the present project, we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD (subthalamic deep brain stimulation (STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and hyperkinetic), using a simple motor task.
Detailed Description
To define the link between the characteristics of neuronal oscillations (frequency, amplitude, phase relationship) within the cortico-subcortical network and the movement, we designed a simple motor task of gripping/pulling a lever. The LFPs will be collected at the cortical and subcortical levels (STN) during the motor task using a high-resolution EEG (HR-EEG) and the Percept™ system (Medtronic). Recordings will be realized in four conditions: without pharmacological treatment and without stimulation (Off condition), without pharmacological treatment and during stimulation (DBS condition), during pharmacological treatment and without stimulation (DOPA condition) and during pharmacological treatment and stimulation (DOPA+DBS condition).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male or Female
- •18 to 75 years-old
- •With idiopathic Parkinson's disease
- •Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
- •Able to perform the simple motor task
- •Patients covered by a health insurance scheme
- •Giving free, informed, written consent signed by the participant and the investigator.
Exclusion Criteria
- •Be incapable of giving consent personally.
- •Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
- •Being pregnant or breastfeeding
- •Present a serious and/or decompensated somatic or psychiatric illness.
Outcomes
Primary Outcomes
Cortico-subcortical electrophysiological coherence
Time Frame: At inclusion (Day 0)
Statistically significant difference in the cortico-subcortical electrophysiological coherence value between a movement performed in hypokinetic condition and a movement performed in hyperkinetic condition
Secondary Outcomes
- Spectral signal power(At inclusion (Day 0))
- Effect of STN-DBS on spectral signal power(At inclusion (Day 0))
- Correlation between semiological characteristics(At inclusion (Day 0))