Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

Not Applicable

Recruiting

• Conditions: Parkinson Disease; Epilepsy
• Interventions: Procedure: High Resolution Electroencephalogram (EEG-HR); Procedure: Stereo-electro-encephalography (SEEG)

• Registration Number: NCT06241924
• Lead Sponsor: University Hospital, Bordeaux

Brief Summary

The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.

The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

Detailed Description

In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed.

The local field potentials (LFPs) will be collected during the same motor task in :

i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings

ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.

Study Timeline

• Study First Submitted: 2024-01-26
• Study First Submitted QC: 2024-01-26
• Status Verified: 2024-02
• Study Start: 2024-02-05
• Study First Posted: 2024-02-05
• Last Update Submitted: 2024-02-08
• Last Update Posted: 2024-02-12
• Primary Completion: 2027-02-05
• Study Completion: 2027-02-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
parkinson disease	High Resolution Electroencephalogram (EEG-HR)	-
Epilepsy	Stereo-electro-encephalography (SEEG)	-

Primary Outcome Measures

Name	Time	Method
difference in the cortico-subcortical electrophysiological coherence value	Day 1	difference in the cortico-subcortical electrophysiological coherence value between normal movement (control condition) and hypo- or hyperkinetic pathological movement

Trial Locations

Locations (1)

CHU de Bordeaux; 🇫🇷 Bordeaux, France