Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- the understanding of the mechanisms underlying the propagation of pathological oscillatory activities in PD
研究概览
简要总结
Neuronal activity in circuits between the basal ganglia (BG) and motor cortical areas is abnormally synchronised and rhythmic. The oscillatory activity prevails at 8-30 Hz in untreated Parkinson's Disease (PD) and its amplitude at both subthalamic and cortical levels inversely correlates with motor impairment. Moreover, these different levels in BG-cortical loops are coherent in this frequency band. The 8-30 Hz activity is suppressed by treatment following treatment with dopaminergic drugs and is partially suppressed prior to and during voluntary movements. An unanswered question is how do BG-cortical loops become so prominently engaged in this oscillatory activity? One possible explanation is that the resonance frequencies of the loops fall in the 8-30 Hz band in the untreated state, so that oscillations in this band are transmitted particularly well. This hypothesis was confirmed in a previous series of experiments.The aim is to determine whether the resonance frequency within BG-cortical loops is correlated to the BG-cortical coherence frequency (with 20 subjets during 24 months).
详细描述
Methods: Record STN-cortex LFP coherence pattern and then stimulate STN (at 0, 5, 10, 15, 20, 25, 30 Hz) in newly implanted patients at rest and during simple and complex motor tasks while recording the steady state evoked potential over the cortex using EEG. The resonance frequency will be calculated as previously (Eusebio et al, Brain 2009). Experiments will be carried out both in the OFF medication and ON medication condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's disease idiopathique evolving for more than 5 years
- •Dopa-Sensibility superior to 50 %
- •Electrodes of stimulation implanted in 2 NST at Timone (Pr PERAGUT)
排除标准
- •Bad tolerance of the condition OFF Dopa and\or OFF stimulation
研究组 & 干预措施
dopamine
ON DOPA:The patient will take his usual treatment with dopamine
干预措施: subthalamo-cortical loops stimulation in a one-sided and bipolar way (Other)
without dopa
OFF Dopa: The patient will be deprived of his treatment usual dopaminergique for at least 12 hours
干预措施: subthalamo-cortical loops stimulation in a one-sided and bipolar way (Other)
结局指标
主要结局
the understanding of the mechanisms underlying the propagation of pathological oscillatory activities in PD
时间窗: 24 months
次要结局
- may provide a basis for different therapeutic strategies(24 months)