Changes of the Neuronal Activity in the Subthalamic Nucleus Under Propofol Sedation During Stereotactic Electrode Implantation.
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients
研究概览
简要总结
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
详细描述
Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Candidate for Deep Brain Stimulation Surgery.
- •Informed concent obtained.
排除标准
- •Suspected difficult intubation (by history or physical examination).
- •Allergy to Propofol, eggs or soy-beans.
- •History of sleep apnea syndrome.
结局指标
主要结局
Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients
时间窗: Within 24 hours needed to analyse the data
次要结局
未报告次要终点