Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation

Not Applicable

• Conditions: Movement Disorders; Effect of Remifentanil
• Interventions: Drug: Remifentanil

• Registration Number: NCT00588926
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who has to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the basal ganglia.

The purpose of this study is to detect possible changes in the electrical activity of the basal ganglia related to remifentanil sedation. electrical activity of single neurons will be recorded before, during and after sedation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2007-12
• Study First Submitted: 2007-12-30
• Study First Submitted QC: 2007-12-30
• Last Update Submitted: 2007-12-30
• Study First Posted: 2008-01-09
• Last Update Posted: 2008-01-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with movement disorder, who are candidates for implantation of deep brain stimulation electrode.

Exclusion Criteria

• Suspected difficult intubation
• history of sleep apnea
• known allergy for remifentanil

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
A	Remifentanil	The patients get a period of sedation with remifentanil, before, during and after which, the changes in the electrical activity of the Basal Ganglia is recorded.

Primary Outcome Measures

Name	Time	Method
Electrical activity in the basal ganglia	During the experiment