Waikato Follow-up Study of People Admitted to Hospital with Chronic Obstructive Pulmonary Disease

Not Applicable

Completed

• Conditions: chronic obstructive pulmonary disease; heart failure; Respiratory - Chronic obstructive pulmonary disease; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12612000548831
• Lead Sponsor: Department of Respiratory Medicine, Waikato Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Physician diagnosis of COPD.
Fixed airflow obstruction (FEV1/FVC <70% and FEV1<80% of predicted) at presentation, in the last 6 months or at 30-day follow up.
Over 40 years of age.
At least 10pack years smoking history.
Acute exacerbation of COPD as defined by dyspnoea, cough or sputum purulence severe enough to warrant hospital admission, respiratory failure or change in mental status due to COPD.
In the patients receiving non-invasive ventilation, arterial blood gas indices of hypercapnic respiratory failure.

Exclusion Criteria

Respiratory physician diagnosis of interstitial lung disease or bronchiectasis.
Radiological diagnosis of pneumonia.
Known diagnosis of clinically significant valvular heart disease.
Known diagnosis of other terminal illness with prognosis less than 2 years.
Inability to perform spirometry.
Patient refusal to participate in the study or unable to give informed consent.
Likely to leave Waikato region or become uncontactable during follow-up period.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cardiac biomarkers (N-terminal pro-brain natriuretic peptide, NT-proBNP and troponin T) levels[at presentation, 12 hours, 72 hours (or on day of discharge from hospital whichever is earlier) and at 30 days following hospitalisation (stable).];cardiac functional indices from cardiac imaging - cardiac magnetic resonance imaging (CMR) - in patients with elevated cardiac biomarkers i.e. NT-proBNP[during hospitalisation (exacerbation) and 30-day follow up (stable)]

Secondary Outcome Measures

Name	Time	Method
all cause mortality[during hospitalisation, at 30 days and at 1 year follow-up];further exacerbations and hospitalisations from patient interview and data linkage to patient medical records[at 30 days and at 1 year follow-up];cardiac events from patient interview and data linkage to patient medical records[at 30 days and at 1 year follow-up];beta-agonists blood level[at presentation];inflammatory markers blood levels[at presentation and at 30 days follow up]