Randomised double blind study to investigate the effect of oxygen versus air driven nebulisers on partial pressure of arterial carbon dioxide in patients with an exacerbation of chronic obstructive pulmonary disease.

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease (COPD); Respiratory - Chronic obstructive pulmonary disease

• Registration Number: ACTRN12615000389505
• Lead Sponsor: Professor Richard Beasley

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-28
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

i. Ninety patients admitted to Hutt Valley or Wellington Regional Hospital medical inpatient wards with a primary admission diagnosis of an exacerbation of COPD.
ii. Participants must have the mental capacity to allow them to provide written informed consent.

Exclusion Criteria

i. Age <40 years at time of randomisation
ii. Requirement for assisted non-invasive ventilation at time of randomisation
iii. Baseline PtCO2 >60mmHg at time of randomisation
iv. Requirement for greater than or equal to 4L/min of oxygen via nasal cannulae to maintain SpO2 between 88-92% prior to or during titration
v. Any other condition which, at the investigator’s discretion, is believed may present a safety risk or impact the feasibility of the study or the study results (including pregnancy or breastfeeding).

Study & Design

• Study Type: Interventional
• Study Design: Not specified