PET for Registration of Inflammation in the Vascular wall of Intracranial
<br>Aneurysms
- Conditions
- Unruptured intracranial aneurysm10007963
- Registration Number
- NL-OMON44673
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
* Age * 18 year
* Presence of an unruptured intracranial aneurysm
* Standard of care decision to treat the aneurysm
* The aneurysm is surgically accessible
* Aneurysm wall sampling is deemed possible by the surgeon
* Written informed consent is obtained
Technical impairments to perform the study
* Incapacity to lie in prone position for 60 minutes
* Aneurysm size smaller than PET detection rate (<7 mm)
* Physical restrictions, e.g. morbid obesity
* Claustrophobia
o Evidence of active infection requiring antibiotic therapy
o Pregnancy or lactation
o Renal insufficiency (estimated glomerular filtration rate < 60
ml/min/1.73 m2)
o Known allergy to gadolinium contrast agent
o Patients with pacemakers, defibrillators, other implanted electronic
devices, or possible metal particles
o Treatment with metformin
o Multiple myeloma (Kahlers disease)
o Waldenstrom macroglobulinemia
o Myasthenia gravis
o Pheochromocytoma
o Mastocytosis
o Thyroid cancer
o Planned thyroid scan
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Detection of inflammation by 18F-IL2 PET, related to the gold standard<br /><br>(histopathology/molecular analysis).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Analysis of interobserver variability in 18F-IL2 PET interpretation.</p><br>