NL-OMON37901已完成不适用
CLINICAL PHARMACOKINETICS OF ROPIVACAINE USING LOCAL INFILTRATION ANESTHESIA (LIA) TECHNIQUE IN THE TOTAL KNEE ARTHROPLASTY: A PILOT STUDY - PHARO
Reinier de Graaf Groep0 个研究点目标入组 10 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Totaal knee arthroplasty surgery
- •- Age older than 18 years
- •- Willing to participate in the study after consultation and written informed consent after Pre-Operative Screening (POS)
排除标准
- •- Known allergy to amide type local anaesthetics or for any other drugs used routinely during this type of surgery
- •- Mentally retarded
- •- Taking opiates or antiemetics (other than used in the protocol and used prior to the POS)
- •- Taking CYP1A2 inhibitors
- •- Taking CYP3A4 inhibitors
- •- Liver failure (ALAT, ASAT, gamma-GT and bilirubin > 3 times upper reference value)- Renal failure (GFR <30 ml/min)
- •- Known alcohol (drink more than 5 alcohol units in any one day), drug or medication abuse. (noted during the POS)
- •- Renal failure (GFR <30 ml/min, determined with measuring the serum creatin and using the Cockroft-Gault formula)
- •- Severe obesity (BMI *40)
研究者
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