Difference between anesthetic agents on liver damages after liver resectio
Phase 2
- Conditions
- metastatic liver tumor
- Registration Number
- JPRN-UMIN000034798
- Lead Sponsor
- ational Cancer Center
- Brief Summary
The primary and key secondary endpoints, peak AST and peak ALT three days after surgery, were significantly higher in the sevoflurane group than in the propofol group. Although there was significantly different in the operation time between groups, there was no significant difference in the ischemic time may affect postoperative AST and ALT. Therefore, the effect of the difference of operation time on outcomes is considered to be limited. In conclusion, a hepatoprotective effect of propofol is suggested.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 58
Inclusion Criteria
Not provided
Exclusion Criteria
1. known allergy of study drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method max value of the aspartate aminotransferase during postoperative 3 days
- Secondary Outcome Measures
Name Time Method max value of the alanine transaminase and total bilirubin during postoperative 3 days and postoperative complication defined by JCOG postoperative complication criteria according to Clavien-Dindo Classification grade 2 or more.