Why methylphenidate is not successful in cocaine-dependent ADHD patients: a SPECT study comparing DAT before and after methylphenidate treatment in ADHD patients with and without cocaine dependence.
Recruiting
- Conditions
- cocaine addiction, cocaine verslaving, ADHD, methylphenidate, methylfenidaat
- Registration Number
- NL-OMON26472
- Lead Sponsor
- Crunelle CL, Booij J, Van den Brink W
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. Male, age 18-60 years;
2. Current DSM-IV diagnosis of adult ADHD for all participants;
Exclusion Criteria
1. Currently dependent on any substance other than cocaine or nicotine;
2. Severe neurological or psychiatric disorders or diseases (e.g., psychosis, bipolar depression, Parkinson¡¯s disease, or dementia) that require psychotropic medications;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effects of a standard dose of methylphenidate (MPH) on Dopamine Transporter (DAT) occupancy in ADHD patients with and without cocaine dependence, in terms of:<br /><br>1. Striatal occupancy of the DAT;<br /><br>2. Symptoms of ADHD;<br /> <br>3. Neurocognitive functions associated with ADHD;<br /> <br>4. Drug use/craving (in the ADHD+SUD group);<br /> <br>5. Relations between DAT occupancy, ADHD symptoms, cognitive functions, and drug use/craving.
- Secondary Outcome Measures
Name Time Method