Why methylphenidate is not successful in cocaine-dependent ADHD patients: A SPECTstudy comparing DAT before and after methylphenidate treatment in ADHD patientswith and without cocaine dependence.
Recruiting
- Conditions
- ADHD, substance use dependence, SUD, cocaine
- Registration Number
- NL-OMON24052
- Lead Sponsor
- Academic Medical Centre, University of Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. Male, age 18-60 years;
2. Current DSM-IV diagnosis of adult ADHD for all participants;
Exclusion Criteria
1. Currently dependent on any substance other than cocaine or nicotine;
2. Severe neurological or psychiatric disorders or diseases (e.g., psychosis, bipolar depression,
Parkinson’s disease, or dementia) that require psychotropic medications;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dopamine transporter (DAT) availability before and after 2 weeks MPH treatment, assesed using 123I-FP-CIT single photon emmision computed tomography (SPECT).
- Secondary Outcome Measures
Name Time Method 1. ADHD symptom improvement (assessed using the ASRS questionnaire);<br /><br>2. Cocaine craving (assessed using the OCDUS and a visual analogue scale).