Study of Human Brain-Gut Axis and Gut Microbiome In Patients With Brain Lesions - Repository for Neuroscience Research
概览
- 阶段
- 不适用
- 干预措施
- Non-Interventional Study
- 疾病 / 适应症
- Malignant Central Nervous System Neoplasm
- 发起方
- Mayo Clinic
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Establish the Mayo Clinic Florida Tumor-Gut Axis Biorepository
- 状态
- 招募中
- 最后更新
- 2个月前
概览
简要总结
This study explores how microorganisms in the gut can affect the growth and progression of brain tumors.
详细描述
PRIMARY OBJECTIVES: I. To establish a Mayo Clinic Florida Brain Tumor-Gut Axis Human Biorepository by sequential collection of fecal, urine, blood, saliva, and/or tissue samples and clinical patient information. II. To use spatial transcriptome/proteomics/multi-omics coupled with microbiome data from various sources including brain tissue and stool samples to understand how microbiota could impact disease development, progression, and treatment response in patients with brain cancer. III. To study the effect of microbiome and potential relationships and/or microbiome reconstruction to impact patient's clinical outcomes including chemo, radiation, immunotherapy and/or cellular therapy. OUTLINE: This is an observational study. Participants undergo blood, tissue, saliva, urine and stool sample collection and complete questionnaires on study.
研究者
入排标准
入选标准
- •All patients undergoing resection for a tumor of the central nervous system and associated controls are eligible to participate in this study.
排除标准
- •Excluded samples will be from patients younger than 18 years old. There are no exclusions due to race/sex.
研究组 & 干预措施
Observational
Participants undergo blood, tissue, saliva, urine and stool sample collection and complete questionnaires on study.
干预措施: Non-Interventional Study
结局指标
主要结局
Establish the Mayo Clinic Florida Tumor-Gut Axis Biorepository
时间窗: Approximately 1 year, or until samples have been collected based on scheduled treatment.
Biological samples such as stool, urine, blood, saliva, and/or tissue will be collected for storage in the Tumor-Gut Axis Biorepository. Samples may be collected at any of the following time periods during study participation: before/after steroid therapy, before/after surgical intervention, before/after radiation therapy, and before/after chemotherapy.