NL-OMON49515CompletedNot Applicable
Effect of prolonged cholesterol lowering treatment on trained immunity of monocytes in patients with elevated levels of LDL-cholesterol - Prolonged cholesterol lowering and TRIM
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •- Aged 18 years or older
- •- They are eligible for participation if they fulfil the criteria for
- •*possible* FH (3-5 points), *probable* FH (6-8 points) or *definitive* FH (>8
- •points), according to the Dutch Lipid Clinic Network diagnostic criteria for
- •familial hypercholesterolemia and untreated LDL levels >4.9 mmol/l and
- •requiring lipid lowering treatment according to the treating physician
- •- No previous cardiovascular events
- •- Written informed consent
- •Control subjects:
- •- Age 18 years or older
- •- LDL cholesterol <3.5 mmol/l
- •- No previous cardiovascular events
- •- Written informed consent
Exclusion Criteria
- •- Current lipid lowering treatment or treatment with lipid lowering drugs in
- •the past year.
- •- Age <18 years
- •- Inability to personally provide written informed consent (e.g. for linguistic
- •or mental reasons)
- •- Current treatment for maliganancy
- •- Acute or chronic infections with fever at the time of participation
- •- Medical history of any disease associated with immune deficiency (either
- •congenital or acquired, including chemotherapy, chronic steroid use, organ
- •transplant)
- •- Clinically significant infections within 1 months prior to study entry
- •(defined as fever >38.5)
- •- Previous vaccination within 1 months prior to study entry
- •- Chronic use of anti-inflammatory drugs such as NSAIDs (acetylsalicylic acid
- •<100 mg/day excluded
Investigators
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