Effects of Aggressive Lipid Lowering Therapy With Atorvastatin on the Fibrous cap Thickness of Thin-cap Fibroatheroma: Three-Vessel Optical Coherence Tomography and Intravascular Ultrasound Study

Not Applicable

• Conditions: Acute Coronary Syndrome

• Registration Number: JPRN-UMIN000003620
• Lead Sponsor: Hyogo College of Medicine Cardiovascular Division

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-05-17
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

1. Patients who will undergo elective percutaneous coronary intervention, 2. Patients who received thrombolytic therapy 3. Previous statin treatment 4. Severe left ventricular dysfunction (Ejection fraction <40% by echocardiogram), 5. Uncontrolled severe diabetes mellitus (HbA1c >12.0%).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
For the plaques evaluated by OCT, what are the differences in plaque-stabilizing effects of atorvastatin in plaques with different characteristics (fibrous cap thickness)?

Secondary Outcome Measures

Name	Time	Method
1. Are LDL-C and fibrous-cap thickness inversely-correlated? 2. Are plaque volume and fibrous-cap thickness inversely-correlated? 3. Does atorvastatin suppress new plaque formation?