Calcium Intake and Fat Excretion - an Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 158
- 试验地点
- 1
- 主要终点
- Total fat and energy excretion
研究概览
简要总结
The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.
详细描述
Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.
The aim of this study is to examined for an association between habitual calcium intake and fecal energy and fat excretion, concentrations of substrates involved in energy metabolism, blood pressure and body weight
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 18 - 50 years
- •weight stable within 4 months prior to the inclusion
排除标准
- •pregnant or lactating
- •uses cholesterol lowering drugs
- •suffering from, now or previously, any gastrointestinal diseases
- •elite athletes
- •participation in other concomitant trial
结局指标
主要结局
Total fat and energy excretion
时间窗: 5 days
Total fat and energy excretion in faeces during the test period of 5 consecutive days
次要结局
- Selected genetic variations(1 day)
- Gut micro flora(1 day)
- p-PTH(1 day)
- NMR-spectroscopy based metabonomics profiling of urin(1 day)
- blood pressure(1 day)
- p-vitamin D(1 day)
- Blood lipids and cholesterol(1 day)
- calcium excretion(2 days)
研究者
Arne Astrup
Department of Human Nutrition
University of Copenhagen