The Effect of Calcium on Fecal Fat and Energy Excretion
- Conditions
- Obesity
- Registration Number
- NCT00519909
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.
- Detailed Description
Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.
The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 15
- healthy meals
- BMI 24-31 kg/m2
- age between 18-50 years
- donation of blood 6 months before and under the study
- milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
- use of dietary supplements 3 months before and under the study
- smoking
- elite athletes
- use of medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Fecal fat excretion, fecal energy excretion, calcium excretion, cholesterol
- Secondary Outcome Measures
Name Time Method Vitamin D, changes in lipolyse
Trial Locations
- Locations (1)
Dept. of Human Nutrition, Faculty of Life Sciences, University of Copenhagen
🇩🇰Frederiksberg, Denmark
Dept. of Human Nutrition, Faculty of Life Sciences, University of Copenhagen🇩🇰Frederiksberg, DenmarkArne Astrup, prof. MDContact+45 3533 2476ast@life.ku.dkJanne K Lorenzen, PhD studentPrincipal Investigator