Profile of protein expression of root canal infections

Not Applicable

• Conditions: Pulp Necrosis; Pulpitis; Periapical Periodontitis; C07.793.237.315; C07.793.237.820; C07.320.830.700

• Registration Number: RBR-7gn68p
• Lead Sponsor: Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-08-07
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

A total of 6 patients were included in this study, 2 with normal pulp (orthodontic indication of extraction), 2 with pulpitis and 2 with chronic apical periodontitis. Therefore, the patients should present the pulp conditions mentioned and for the endodontic treatment of the teeth with inflammation and pulp necrosis, they should be able to be isolated with a rubber dam.

Exclusion Criteria

Patients without systemic disease. Patients whose teeth cannot be restored.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The difference in protein expression of normal, inflamed and necrotic pulp tissue through the proteomic analysis of the dental pulp.;In the inflamed pulp group compared to the normal pulp group, the most expressed proteins were hemoglobins, peroxiredoxins and immunoglobulins, while the less expressed were tubulins. While in the necrotic pulp group, the expression of albumins, immunoglobulins and alpha-2-macroglobulin were increased when compared to the inflamed pulp group.

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes are not expected.