Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 16
- Locations
- 2
- Primary Endpoint
- Sublingual Microcirculatory Variables
Study Overview
Brief Summary
Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these agents interfere or not on microvascular blood flow. The goal of this study was to compare effects of propofol and midazolam infusions on sublingual microcirculation of septic shock patients.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Septic shock patients needing mechanical ventilation in pressure or volume-controlled mode.
Exclusion Criteria
- •age less than 18 years,
- •pregnancy,
- •non-sinus rhythm, and
- •contraindication of daily interruption of sedative drug,
- •mainly with the use of neuromuscular blocking drugs, or
- •patients with intracranial hypertension or epileptical status.
Outcomes
Primary Outcomes
Sublingual Microcirculatory Variables
Time Frame: Just before stopping propofol and thirty minutes after the start of midazolam infusion
Patients were sedated with propofol during the first 24 hours after intubation and with midazolam afterwards.Systemic hemodynamics and perfusion parameters were assessed at two time points: just before stopping propofol and thirty minutes after the start of midazolam infusion. At both steps, four microcirculatory sequences were acquired using sidestream darkfield imaging to access sublingual microcirculation
Secondary Outcomes
No secondary outcomes reported
Investigators
Guilherme Loures Penna
Principal Investigator
Casa de Saúde São José