Association of Sublingual Microcirculation Parameters and Endothelial Glycocalyx Dimensions in Resuscitated Sepsis: A Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Correlations between Perfused Boundary Region (PBR) and Proportion of Perfused Vessels (PPV) measured sublingually
研究概览
简要总结
The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis. Therefore, 30 critically ill septic patients and 10 healthy controls were enrolled.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Correlations between Perfused Boundary Region (PBR) and Proportion of Perfused Vessels (PPV) measured sublingually
时间窗: During ICU stay, an average of 2 days after sepsis onset
Glycocalyx thickness will be measured with PBR (in μm) and PPV will be assessed in percentage. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Correlations between Perfused Boundary Region (PBR) and Perfused Vessel Density (PVD) measured sublingually
时间窗: During ICU stay, an average of 2 days after sepsis onset
Glycocalyx thickness will be measured with PBR (in μm) and PVD will be assessed in mm/mm\^2. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Correlations between Perfused Boundary Region (PBR) and Microvascular Flow Index (MFI) measured sublingually
时间窗: During ICU stay, an average of 2 days after sepsis onset
Glycocalyx thickness will be measured with PBR (in μm) and MFI will be assessed in points. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
次要结局
未报告次要终点