Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock

Not Applicable

Completed

• Conditions: Shock,; Sepsis

• Registration Number: NCT01618396
• Lead Sponsor: Casa de Saúde São José

Brief Summary

Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these agents interfere or not on microvascular blood flow. The goal of this study was to compare effects of propofol and midazolam infusions on sublingual microcirculation of septic shock patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2012-06
• Study First Submitted: 2012-06-11
• Study First Submitted QC: 2012-06-12
• Last Update Submitted: 2012-06-12
• Study First Posted: 2012-06-13
• Last Update Posted: 2012-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Septic shock patients needing mechanical ventilation in pressure or volume-controlled mode.

Exclusion Criteria

• age less than 18 years,
• pregnancy,
• non-sinus rhythm, and
• contraindication of daily interruption of sedative drug,
• mainly with the use of neuromuscular blocking drugs, or
• patients with intracranial hypertension or epileptical status.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Sublingual Microcirculatory Variables	Just before stopping propofol and thirty minutes after the start of midazolam infusion	Patients were sedated with propofol during the first 24 hours after intubation and with midazolam afterwards.Systemic hemodynamics and perfusion parameters were assessed at two time points: just before stopping propofol and thirty minutes after the start of midazolam infusion. At both steps, four microcirculatory sequences were acquired using sidestream darkfield imaging to access sublingual microcirculation

Trial Locations

Locations (1)

Casa de Saude Sao Jose; 🇧🇷 Rio de Janeiro, Brazil