Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Tissue oxygen saturation measured at thenar eminence by Hutchinson(R) tissue oximeter during off-pump coronary artery bypass surgery
研究概览
简要总结
Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass. However, the effect of volatile anesthetics on microcirculation in patients undergoing off-pump coronary artery bypass has not been well conducted.
详细描述
This is a prospective randomized clinical trial investigating the effect of sevoflurane vs. desflurane on tissue microcirculation in patients undergoing off-pump coronary artery bypass surgery. Eligible patients are going to be randomized to receive sevoflurane or desflurane, as a maintenance anesthetic, during the surgery. Tissue oxygen saturation and microcirculatory changes, such as an occlusion and recovery slope, during vascular occlusion test will be recorded during the surgery. The primary end point of the study is the difference in tissue oxygen saturation between the groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for off-pump coronary artery bypass surgery
排除标准
- •any deformity or vascular abnormalities on upper arms
- •cannot receive sevoflurane or desflurane for any reason (muscular diseases, etc)
- •uncontrolled diabetes
- •peripheral vascular disease
- •severe renal dysfunction (end-stage renal disease)
- •refuse to enroll
研究组 & 干预措施
Sevoflurane
Sevoflurane (2 vol%) use as a maintenance volatile anesthetic drug during the surgery
干预措施: Sevoflurane (Drug)
Desflurane
Desflurane (6 vol%) use as a maintenance volatile anesthetic drug during the surgery
干预措施: Desflurane (Drug)
结局指标
主要结局
Tissue oxygen saturation measured at thenar eminence by Hutchinson(R) tissue oximeter during off-pump coronary artery bypass surgery
时间窗: Before induction of anesthesia to the end of the surgery, an average 8 hours
Tissue oxygen saturation measured at thenar eminence by tissue oximeter during surgery in patients receiving sevoflurane or desflurane
次要结局
未报告次要终点
研究者
Youn Joung Cho, MD
Clinical Professor
Seoul National University Hospital