Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Phase 4

Completed

• Conditions: Microcirculation; Anesthetic Complication Spinal
• Interventions: Drug: Desflurane; Drug: Sevoflurane

• Registration Number: NCT03209193
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass. However, the effect of volatile anesthetics on microcirculation in patients undergoing off-pump coronary artery bypass has not been well conducted.

Detailed Description

This is a prospective randomized clinical trial investigating the effect of sevoflurane vs. desflurane on tissue microcirculation in patients undergoing off-pump coronary artery bypass surgery. Eligible patients are going to be randomized to receive sevoflurane or desflurane, as a maintenance anesthetic, during the surgery. Tissue oxygen saturation and microcirculatory changes, such as an occlusion and recovery slope, during vascular occlusion test will be recorded during the surgery. The primary end point of the study is the difference in tissue oxygen saturation between the groups.

Study Timeline

• Study First Submitted: 2017-07-03
• Study First Submitted QC: 2017-07-03
• Study Start: 2017-07-04
• Study First Posted: 2017-07-06
• Primary Completion: 2019-11-07
• Study Completion: 2019-11-07
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-03
• Last Update Posted: 2020-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• scheduled for off-pump coronary artery bypass surgery

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Exclusion Criteria

• any deformity or vascular abnormalities on upper arms
• cannot receive sevoflurane or desflurane for any reason (muscular diseases, etc)
• uncontrolled diabetes
• peripheral vascular disease
• severe renal dysfunction (end-stage renal disease)
• refuse to enroll
• pregnant

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane	Desflurane	Desflurane (6 vol%) use as a maintenance volatile anesthetic drug during the surgery
Sevoflurane	Sevoflurane	Sevoflurane (2 vol%) use as a maintenance volatile anesthetic drug during the surgery

Primary Outcome Measures

Name	Time	Method
Tissue oxygen saturation measured at thenar eminence by Hutchinson(R) tissue oximeter during off-pump coronary artery bypass surgery	Before induction of anesthesia to the end of the surgery, an average 8 hours	Tissue oxygen saturation measured at thenar eminence by tissue oximeter during surgery in patients receiving sevoflurane or desflurane

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of