The Effects of General Anesthesia on Microcirculation of Central and Peripheral Soft Tissue: a Comparison of Inhalational and Intravenous Anesthetics

Not Applicable

• Conditions: Inhalation and Intravenous Anesthesia; Microcirculatory Effects of Anesthesia
• Interventions: Drug: Sevoflurane; Drug: Propofol; Procedure: General anesthesia induction

• Registration Number: NCT02530632
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Effects of different general anesthetics on peripheral microcirculation.

Detailed Description

Human keep body temperature in a narrow range by a variety of regulatory mechanism. Peripheral thermal receptors send signals to central nervous system which regulate body temperature via peripheral effectors, such as vasoconstriction, vasodilatation, shivering, sweating and etc. In patients undergoing general anesthesia, the regulatory mechanism is altered. General anesthesia changes blood distribution in the body, the metabolic rate of muscle, threshold of thermal regulation in the brain and etc, so that heat distribution and microcirculation condition will also change. In this study, near-infrared spectroscopy (NIRS) is used to measure the microcirculatory condition. NIRS is a non-invasive continuous measurement to detect tissue saturation with the method of different wavelength of near-infrared. General anesthesia with inhalational sevoflurane and intravenous propofol is separated into 2 groups. Because of different mechanism of general anesthesia of these 2 anesthetics, different physiologic response may occur. Body temperature and somatic saturation are compared in each group.

Study Timeline

• Study Start: 2015-08
• Study First Submitted: 2015-08-17
• Study First Submitted QC: 2015-08-19
• Study First Posted: 2015-08-21
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-12
• Last Update Posted: 2016-04-13
• Primary Completion: 2016-09
• Study Completion: 2016-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. Breast surgeries under general anesthesia
2. BMI 18.5~30

Exclusion Criteria

1. Cardiac disease
2. Lung disease
3. Renal disease
4. Neurological disease
5. Autonomic nervous system dysfunction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Propofol anesthesia	General anesthesia induction	Anesthesia maintained with intravenous propofol continuous infusion
Sevoflurane anesthesia	General anesthesia induction	Anesthesia maintained with inhalational sevoflurane
Sevoflurane anesthesia	Sevoflurane	Anesthesia maintained with inhalational sevoflurane
Propofol anesthesia	Propofol	Anesthesia maintained with intravenous propofol continuous infusion

Primary Outcome Measures

Name	Time	Method
Somatic saturation	during surgery, approximately 2-4 hr	Change of somatic saturation measured by NIRS

Secondary Outcome Measures

Name	Time	Method
Body temperature	during surgery, approximately 2-4 hr	Nasal and peripheral temperature

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei City, Taiwan