Impact of Nimodipine on Sublingual Microcirculation in Patients With Subarachnoid Hemorrhage - a Prospective Monocentric Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Functional capillary density (FCD)
研究概览
简要总结
Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.
详细描述
SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented [1-6]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adulthood
- •ICU admission
- •diagnosis of non-traumatic subarachnoid hemorrhage
排除标准
- •inherited coagulation disorder
- •rheumatic disease
- •microangiopathy
- •patient of representative refusal
结局指标
主要结局
Functional capillary density (FCD)
时间窗: One week
Parameter describing the perfusion of the microcirculation
Proportion of perfused vessels (PPV)
时间窗: One week
Parameter describing the perfusion of the microcirculation
次要结局
- Vasospasm occurence(One week)
- Circulatory incoherence(One week)