Population Research of Sublingual Microcirculation Data of Healthy Volunteers

Completed

• Conditions: Healthy
• Interventions: Other: No intervention

• Registration Number: NCT02359682
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

This study will enrolled 90 healthy volunteers. The sublingual microcirculation will be examined by sidestreamdark-field videomicroscopy (MicroScan;Microvision Medical, Amsterdam, The Netherlands). Five video sequences (20 s) was obtained from different sublingual sites, and digitally stored the images with code numbers that did not reflect volunteers' information for later offline analysis by automated analysis software (AVA 3.0; Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands).

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-11-05
• Study First Submitted QC: 2015-02-04
• Study First Posted: 2015-02-10
• Primary Completion: 2015-06
• Study Completion: 2015-07
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-11
• Last Update Posted: 2015-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Healthy volunteers aged from 20 to 79 years old
• BMI ranged from 18.5 to 27 kg/m2

Exclusion Criteria

• Systolic blood pressure > 140 mm Hg, diastolic blood pressure > 95 mm Hg, or systolic blood pressure < 90 mm Hg at enrollment
• Body temperature > 37.5 ℃ or < 35.5 ℃ at enrollment
• had been diagnose with any one of the following diseases
• hypertension
• diabetes mellitus
• peripheral arterial occlusive disease
• coronary arterial disease
• liver cirrhosis
• chronic kidney disease
• stroke
• anemia
• asthma
• chronic bronchitis
• any metabolic diseases
• any hematologic disease
• uncured cancer
• chronic uncontrolled infection
• other disease may limit daily activities
• non-native speakers

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Age 20-39	No intervention	Patients aged from 20 to 39 years old.
Age 40-59	No intervention	Patients aged from 40 to 59 years old.
Age 60-79	No intervention	Patients aged from 60 to 79 years old.

Primary Outcome Measures

Name	Time	Method
Total small vessel density of sublingual small vessels	Once at enrollment	Total small vessel density will be measured by Microscan and analyzed by AVA 3.0 software.

Secondary Outcome Measures

Name	Time	Method
Perfused small vessel density of sublingual small vessels	Once at enrollment	Perfused small vessel density will be measured by Microscan and analyzed by AVA 3.0 software.

Trial Locations

Locations (1)

National Taiwan University Hospital, anesthesiology department; 🇨🇳 Taipei, Taiwan