Characteristics and Prognosis of Jejunoileal Gastrointestinal Stromal Tumors (GISTs) in the Era of Imatinib. A Comparative Retrospective Study With Gastric GISTs.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- Expression of DOG1
研究概览
简要总结
Introduction: Gastrointestinal Stromal Tumors (GISTs) located in the jejunum or ileum (JI-GIST) are considered of worse prognosis compared to other locations. It has been suggested that this dogma should be revised. The aim of this study is to describe the characteristics of jejunoileal GISTs and its prognosis; and to compare them with gastric GISTs in the era of imatinib.
Patients and methods: We retrospectively reviewed the clinical histories of all the patients diagnosed with GISTs between January 2000 and November 2016. Clinical and pathological data, as well recurrence, metastatic, disease-free survival (DFS) as overall (OS) rates of patients with JI-GIST or gastric GIST (G-GIST) were collected and compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any kind of primary mesenchymal tumor of the gastrointestinal tract with a histomorphological and immunohistochemical (CD117 (+) and/or DOG1 (+)) profile consistent with GIST.
排除标准
- 未提供
结局指标
主要结局
Expression of DOG1
时间窗: 15 years
Number of patients with immunohistochemical expression of DOG1
Deceased
时间窗: 15 years
Number of patients deceased during follow-up.
KIT Gene mutation
时间窗: 15 years
Number of patients with a molecular analysis positive for KIT mutation
Expression of CD117
时间窗: 15 years
Number of patients with immunohistochemical expression of CD117
Location
时间窗: 15 years
Location of the tumor (gastric o jejunoileal)
PDGFRA Gene mutation
时间窗: 15 years
Number of patients with a molecular analysis positive for PDGFRA mutation
Recurrence
时间窗: 15 years
Number of patients with recurrence after treatment with tyrosinkin inhibitors.
次要结局
未报告次要终点
研究者
David Ferreras
Principal Investigator
Hospital Universitario Virgen de la Arrixaca