Effects of Non-invasive Ventilation on Rehabilitation Outcome in COPD-patients
Not Applicable
Terminated
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NCT01384981
- Lead Sponsor
- Schön Klinik Berchtesgadener Land
- Brief Summary
The aim of the study is to find out if nocturnal non-invasive ventilation during pulmonary rehabilitation increases exercise capacity and quality of life more than pulmonary rehabilitation alone.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 31
Inclusion Criteria
- confirmed diagnosis of COPD in stages GOLD III/ IV
- receiving optimized medical treatment and long term oxygen therapy if needed
- patients consent to participate in this trial
- no treatment with NIV in the last 4 weeks
- treatment with NIV in the last 4 weeks due to an acute exacerbation
Exclusion Criteria
- treatment with NIV in the last 4 weeks (except due to an acute exacerbation)
- Intolerance to perform NIV
- Acute exacerbation at baseline or during PR
- Hypercapnia > pCO2 55mmHg
- Inability to perform a 6 minute walking test
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method change in 6 minute walking distance day 1 and 25 change in 6 minute walking distance from baseline to day 25
- Secondary Outcome Measures
Name Time Method change in quality of life (chronic respiratory questionnaire, CRQ) day 1 and 25 change in CRQ-Score from baseline to day 25
change quality of life (Saint George´s Respiratory Questionnaire, SGRQ) day 1 and 25 change in SGRQ-Score from baseline to day 25
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie improved exercise capacity in COPD patients with non-invasive ventilation during pulmonary rehabilitation?
How does nocturnal non-invasive ventilation compare to standard pulmonary rehabilitation in COPD GOLD III/IV patients regarding quality of life outcomes?
Are there specific biomarkers that predict enhanced response to non-invasive ventilation combined with pulmonary rehabilitation in severe COPD?
What adverse events are associated with long-term nocturnal non-invasive ventilation in COPD GOLD III/IV patients undergoing rehabilitation?
How do combination approaches of non-invasive ventilation and pulmonary rehabilitation influence hypercapnia and respiratory muscle fatigue in advanced COPD?
Trial Locations
- Locations (1)
Schön Klinik Berchtesgadener Land
🇩🇪Schönau am Königssee, Germany
Schön Klinik Berchtesgadener Land🇩🇪Schönau am Königssee, Germany