Evaluation of the Effectiveness of Non-invasive Ventilation on the Reperfusion Pulmonary Edema Post Pulmonary Artery Angioplasty in the Post Embolic Pulmonary Hypertension
- Conditions
- Reperfusion Pulmonary Edema
- Registration Number
- NCT02548091
- Lead Sponsor
- Centre Chirurgical Marie Lannelongue
- Brief Summary
The purpose of this study is to determine whether Non Invasive Ventilation are effective in prevention of reperfusion pulmonary edema after pulmonary artery angioplasty. Our hypothesis is that administration of Non Invasive Ventilation during the procedure and systematically in post procedure period is a protective factor against the development and severity of reperfusion pulmonary edema.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 236
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Lung Injury Score. Daily during hospitalization in the PACU on day 1 to 7.
- Secondary Outcome Measures
Name Time Method Computed tomography (CT) score 2 years Pulmonary Vascular Index (PVI) measures 2 years PVI is measure by thermodilution technique using a Pulse-Induced Contour Cardiac Output system (PICCO
Doppler pulsatility of the portal vein and its pulsatility ratio 2 years Assays of plasma inflammatory markers (InterLeukin-6 , IInterLeukin-8, InterLeukin-10). 2 years The concentration will be given in pg/mL
Extravascular Lung Water (EVLW) measures. 2 years EVLW is measure by thermodilution technique using a Pulse-Induced Contour Cardiac Output system (PICCO). The unit of EVLW is mL/Kg
Trial Locations
- Locations (1)
Centre Chirurgical Marie Lannelongue
🇫🇷Le Plessis Robinson, France
Centre Chirurgical Marie Lannelongue🇫🇷Le Plessis Robinson, France