NCT00523497
Terminated
Not Applicable
Noninvasive Mechanical Ventilation in Severe Community-Acquired Pneumonia and Acute Hypoxemic Respiratory Failure. A Prospective, Randomized and Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Community Acquired Pneumonia.
- Sponsor
- Hospital Privado del Sur
- Locations
- 1
- Primary Endpoint
- The primary aim of this study was to compare the effects of NIMV on mortality rate and length of stay at the ICU with the effects of CMV
- Status
- Terminated
- Last Updated
- 18 years ago
Overview
Brief Summary
The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal intubation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •The criteria for the diagnosis of SCAP included:
- •Blood systolic pressure lower than 90 mmHg or blood diastolic pressure lower than 60 mmHg
- •RR higher than 30 breaths per minute
- •PaO2/FiO2 lower than 250 while breathing through a Venturi mask with a 50% inspired oxygen fraction (FiO2)
- •Bilateral or multiple lobar infiltrations evidenced by thorax X-ray, and
- •Use of vasopressor drugs
Exclusion Criteria
- •Exclusion criteria included:
- •Acute cardiogenic pulmonary edema
- •Severe haemodynamic instability (arterial systolic pressure lower than 70 mmHg) or requirements of vasoactive drugs
- •Glasgow score equal to or lower than 9 or requiring OTI for airway protection or for recent pulmonary resucitation
- •Antecedents of respiratory failure resulting from neuromuscular pathology
- •Failure of two or more organs
- •Facial deformities; and
- •Recent facial, aesophagic and gastric surgeries
Outcomes
Primary Outcomes
The primary aim of this study was to compare the effects of NIMV on mortality rate and length of stay at the ICU with the effects of CMV
Time Frame: 3 years
Secondary Outcomes
- The secondary aims were to evaluate the incidence and the complications of OTI as well as to compare the improvements in the gas exchange.(3 years)
Study Sites (1)
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