urse Based Genetic Counseling for Hereditary Womens Cancer

Not Applicable

• Conditions: Health Condition 1: C56- Malignant neoplasm of ovary

• Registration Number: CTRI/2021/06/034308
• Lead Sponsor: Chittaranjan National Cancer Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

a) All non-mucinous epithelial ovarian cancer irrespective of their age

b) All first degree and second degree relatives of women diagnosed with

epithelial ovarian cancer and found to have deleterious mutation in BRCA1 or 2

c) If further funding is available: Then testing according to the NCCN guidelines

for Hereditary Breast and Ovarian cancer risk assessment

1. Personal history of breast cancer and �1 of these:

ïâ??· Diagnosed at age ââ?°Â¤45 years

ïâ??· Diagnosed at age ââ?°Â¥50 years with ââ?°Â¥1 close blood relatives with breast cancer at

age 50 years and/or �1 close blood relatives with epithelial ovarian cancer at

any age

ïâ??· 2 breast primaries when first breast cancer diagnosis occurred at age ââ?°Â¤50 years

ïâ??· Diagnosed at age ââ?°Â¤60 years with a triple negative breast cancer

ïâ??· Diagnosed at age ââ?°Â¤50 years with a limited family history

ïâ??· Diagnosed at any age with ââ?°Â¥2 close blood relatives with pancreatic cancer at

any age

Close male blood relative with breast cancer

Individual of ethnicity associated with higher mutation frequency (e.g.,

Ashkenazi Jewish)

Personal history of epithelial ovarian cancer

ïâ??· Personal history of male breast cancer

Personal history of pancreatic cancer at any age with �2 close blood relatives

with breast and/or ovarian cancer and/or pancreatic cancer at any age

2. No personal history of breast cancer, but �1 of these:

ïâ??· First- or second-degree blood relative meeting any of the above criteria

Third-degree blood relative with breast cancer and/or ovarian cancer with �2

close blood relatives with breast cancer (�1 with breast cancer at age �50

years) and/or ovarian cancer

Exclusion Criteria

Any patient who does not meet the inclusion criteria

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify whether implementation of nurse led genetic clinic <br/ ><br>supported by patient public involvement is cost-effective <br/ ><br>Identifying more individuals at risk of cancers through awareness and screening campaigns. <br/ ><br>Improving the uptake of genetic testing and referrals. <br/ ><br>In the longer term, reduction in women being diagnosed with advanced breast-ovarian cancers <br/ ><br>in a defined geographical area <br/ ><br>5. Economic analysis of such approach where the cost of <br/ ><br>facility is part-borne by local communityTimepoint: 3 years