Predictive Value of Dynamic Contrast Enhancement MRI on a Cerebral Tumor Response to Gamma Knife Treatment
- Conditions
- Cerebral Metastases
- Registration Number
- NCT00156585
- Lead Sponsor
- Martin Lepage
- Brief Summary
Hypothesis: the pattern of MRI contrast enhancement after gadolinium injection is different in tumors that respond well to gamma knife.
We are going to acquire sequential T1-weighted images of brain lesions before, during and after injection of Gd-DTPA. This will be repeated before and after a treatment with gamma knife. We will then analyse our results to see if there are common enhancement characteristics between lesions that will respond well to the radiosurgery treatment. Response will be clinically assessed by tumor volume as determined by MRI approximately 4 to 6 months after treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 31
- Patient with intracerebral lesion benign or malignant wich are not concerned by the exclusion criteria
- Pancranial radiotherapy
- Residual postop lesion
- Gliomas
- Patients < 18 years old
- Anterior allergic reaction to gadolinium
- Claustrophobia.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MRI parameters Before treatment with the Gamma Knife Tumor volume, Ktrans, ve, time at maximum signal enhancement, maximum signal difference, ADC, basal T1 value
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Faculté de médecine, Université de Sherbrooke
🇨🇦Sherbrooke, Quebec, Canada