Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities
Terminated
- Conditions
- Glioblastoma Multiforme
- Interventions
- Other: dynamic contrast enhanced magnetic resonance imaging
- Registration Number
- NCT00589095
- Lead Sponsor
- Yale University
- Brief Summary
The purpose of this study is to determine whether dynamic contrast enhanced MRI (DCE MRI) and high diffusion weighting MRI may be used to distinguish between favorable and unfavorable responses to therapy of glioblastoma multiforme. Imaging data will be correlated with histopathologic findings and clinical responses to radiation therapy with or without chemotherapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- The presence of a primary brain tumor that cannot be completely resected that requires radiation therapy with or without chemotherapy.
Exclusion Criteria
- Patients who do not have a primary brain tumor or who are unable to tolerate the environment of the MRI scanner
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 1 dynamic contrast enhanced magnetic resonance imaging -
- Primary Outcome Measures
Name Time Method To detect the early "local" treatment responses from the physician recognized GBM "gross tumor volume" (GTV) Upon completion of study
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States