Risk Factors and Prediction Model of Cancer-associated Venous Thromboembolism

Recruiting

• Conditions: Venous Thromboses; Neoplasms

• Registration Number: NCT05729464
• Lead Sponsor: Yongsheng Jiang

Brief Summary

The purpose of this study is to identify risk factors of cancer-associated venous thrombosis and develop a prediction model to assist clinicians in tailoring anticoagulant therapy.

Detailed Description

Venous thromboembolism (VTE) is a prevalent complication in cancer patients. Compared with the general population, patients with tumors are four to seven times more likely to develop venous thrombotic events. A population-based cohort study showed that the incidence of VTE in these patients has increased steadily over the past decade. Cancer-associated thrombosis may result in discontinuation of antineoplastic therapy, decreased quality of life, and increased mortality. Clinical trials indicate that prophylactic anticoagulation leads to a significantly lower rate of thrombotic disorders. However, due to the fact that thromboprophylaxis treatment increases the risk of bleeding complications and that the risk of VTE varies widely among individuals, only patients at high risk of thrombosis will benefit from primary thromboprophylaxis. In this setting, the use of anticoagulant drugs is challenging. So, the purpose of this study is to identify risk factors of cancer-associated venous thrombosis and develop a prediction model to assist clinicians in tailoring anticoagulant therapy.

Study Timeline

• Study Start: 2022-12-23
• Status Verified: 2023-02
• Study First Submitted: 2023-02-06
• Study First Submitted QC: 2023-02-06
• Last Update Submitted: 2023-02-06
• Study First Posted: 2023-02-15
• Last Update Posted: 2023-02-15
• Primary Completion: 2023-07-01
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 700

Inclusion Criteria

• with a histological diagnosis of cancer.

Exclusion Criteria

• received long-term anticoagulant therapy;
• without a clear primary site of malignancy;
• had a follow-up of fewer than 6 months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cancer-associated venous thrombosis	12 months since receiving anti-cancer therapy	including deep venous thrombosis and pulmonary embolism

Trial Locations

Locations (1)

Tongji Hospital; 🇨🇳 Wuhan, China