The effect of a combination of dietary factors (viscous fibers, vegetable proteins and plant sterols) on cholesterol reduction in hyperlipidemic subjects

Not Applicable

Completed

• Conditions: Hypercholesterolemia; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN72726593
• Lead Sponsor: niversity of Toronto (Canada)

Brief Summary

2008 Results article in https://doi.org/10.1016/j.metabol.2007.08.016 (added 27/10/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-08-10
• Study Completion: 2007-09-30
• Last Update Posted: 8 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 330

Inclusion Criteria

1. 330 persons with hiperlipidemia of both sex, age groups 18 and older
2. Men and post menopausal women with Low-Density Lipoprotein (LDL)-cholesterol levels within 30% of their target goals who are prepared to make a serious commitment to dietary change

Exclusion Criteria

1. Body mass index (BMI) >32 kg/m^2
2. Recent weight loss or gain
3. Recent stroke
4. Myocardial Infarction (MI)
5. Familial hypercholesterolemia, secondary causes of hypercholesterolemia (e.g. hypothyroidism unless treated, renal or liver disease)
6. Cholesterol lowering medications
7. Triglyceride (TG) less than 4.5, blood pressure (BP) more than 145/90
8. Diabetes or major disability or disease, including liver disease, renal failure or cancer

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
DL-cholesterol

Secondary Outcome Measures

Name	Time	Method
Total: High-Density Lipoprotein (HDL) cholesterol, TG, HDL-C, C-Reactive Protein (CRP), Homocysteine, glucose, insulin, waist circumference, blood pressure (BP), diet composition, body weight, and red cell fragility and plant sterol concentrations