Caustic Esophageal Burns in Children and High Doses of Methylprednisolone

Phase 4

Completed

• Conditions: Esophageal Diseases
• Interventions: Drug: methylprednisolon

• Registration Number: NCT02002078
• Lead Sponsor: Sisli Hamidiye Etfal Training and Research Hospital

Brief Summary

Corrosive substance ingestion in childhood is a public health issue in developing countries and several management protocols were proposed to prevent esophageal strictures. The role of corticosteroids in preventing corrosive-induced strictures is controversial. The investigators' aim is to study the influence of high doses of corticosteroids to prevent esophageal strictures.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-02
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2013-11
• Study First Submitted: 2013-11-22
• Study First Submitted QC: 2013-11-28
• Last Update Submitted: 2013-11-28
• Study First Posted: 2013-12-05
• Last Update Posted: 2013-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

-Corrosive substance ingested children with grade IIb esophageal burn

Exclusion Criteria

• Caustic substance ingested chldren grade I, IIa and grade III esophageal burns
• Caustic subtance ingested children with signs of perforation, mediastinitis, peritonitis, sespis
• Caustic substance ingested children with any chronic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Methylprednisolone, caustic burns	methylprednisolon	-

Primary Outcome Measures

Name	Time	Method
Evaluation of stricture development in children with caustic esophageal burns after high doses of methylprednisolone	three years	stricture development was evaluated with endoscopic examination and upper gastrointestinal system series with barium swallow