Administration of Methylprednisolone in prevention of ovarian hyperstimulation syndrome
- Conditions
- Ovarian Hyperstimulation Syndrome.Other obstetric conditions, not elsewhere classifiedO94 , O99
- Registration Number
- IRCT138806181141N6
- Lead Sponsor
- Royan Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 218
Inclusion Criteria: 1.Poly Cystic Ovarian Syndrome patients 2.Indication for IVF/ICSI and Long Protocol ovarian stimulation 3.Age<35 4.Basal FSH=10 5.Normal BMI (20-25) 6.Physical health
1. Allergy to GnRH analogues, FSH and corticosteroids 2. presence of heart failure, recent myocardial infarction, Hypertension, Diabetes mellitus, epilepsy, glaucoma, hypothyroidism, hepatic failure, osteoporosis, peptic ulceration, psychosis, or severe affective disorders and renal impairment. 3. Using drugs that have interaction with corticosteroids such as Cyclosporine, Phenobarbital, Phenytoin, Rifampin, Ketoconazole, Aspirin and Anticoagulants (All of these drugs shouldn’t be used during recent 2 weeks prior to the study and during corticosteroids consumption)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method OHSS occurrence rate. Timepoint: Until 20 days after embryos transfer (ET). Method of measurement: accordance with the Golan 5 grade system.
- Secondary Outcome Measures
Name Time Method Estradiol concentration. Timepoint: on the day before hCG administration. Method of measurement: laboratory results.;Retrieved and injected oocytes number and quality. Timepoint: oocyte retrieval day. Method of measurement: embryology results.;Achieved and transferred embryos number and quality. Timepoint: 48-72 hours after oocyte retrieval. Method of measurement: embryology results.;Chemical pregnancy rate. Timepoint: day 13 after embryo transfer. Method of measurement: laboratory results.;Clinical pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasound results.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasound results.;Cancellation rate. Timepoint: day 13 after embryo transfer. Method of measurement: patient records.