Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Valve Surgery
- Sponsor
- China Medical University, China
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- gut microbiota
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
Detailed Description
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass. Firstly, this study aims to characterize the gut microbiota in patients with valve disease treated with surgery. Secondly, it aims to evaluate microbiota and its influence on postoperative sleep.
Investigators
Wen-fei Tan
Professor
China Medical University, China
Eligibility Criteria
Inclusion Criteria
- •Ethnic Chinese;
- •Age, 18 to 65 years old;
- •Patients undergoing heart valve surgery with cardiopulmonary bypass
Exclusion Criteria
- •Preoperative Pittsburgh Sleep Quality Index global scores higher than 6
- •Cognitive difficulties
- •Partial or complete gastrectomy
- •Previous esophageal surgery
- •Previous treated by radiotherapy or surgery
- •Inability to conform to the study's requirements
- •Body mass index exceeding 30 kg/m2
- •Deprivation of a right to decide by an administrative or juridical entity
- •Ongoing participation or participation in another study \<1 month ago
- •Recent (\< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or traditional Chinese medicine
Outcomes
Primary Outcomes
gut microbiota
Time Frame: from baseline to postoperative 72 hours
This study will characterize the gut microbiota in one group of 36 patients before and after heart valve surgery
Secondary Outcomes
- serum metabolites(from baseline to postoperative 72 hours)
- postoperative sleep(on the second postoperative night from 20:00 to 6:00)