The Change of Gut Microbiota After Bowel Preparation and the Effect of Probiotics: Randomized Controlled, Open-label Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The effect of probiotics on the change of gut microbiota after bowel preparation.
研究概览
简要总结
The purpose of this study is to investigate the relationship between the change of intestinal bacterial flora and the recovery, and the incidence of symptoms such as abdominal discomfort after colonoscopy. And the investigators will also analyze the effects of probiotics on the degree of change, recovery, and symptom development in intestinal flora.
详细描述
The investigators divided two groups. (total number = 100 subjects)
- with probiotics group - 50 subjects
- Participants included in this group will be taken probiotics for 1 month after bowel preparation for colonoscopy.
- without probiotics group - 50 subjects
- Participants included in this group will not be taken probiotics for 1 month after bowel preparation for colonoscopy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adults between the age of 30 and 70
排除标准
- •subjects with cancer or IBD (inflammatory bowel disease)
- •subjects with history of abdominal surgery
- •subjects who take medication related to gastrointestinal motility within 3 months
- •subjects who take antibiotics within 3 months
研究组 & 干预措施
with Probiotics
Participants included in this group will be taken probiotics for 1 month after bowel preparation for colonoscopy.
干预措施: Duolac (Drug)
结局指标
主要结局
The effect of probiotics on the change of gut microbiota after bowel preparation.
时间窗: eight months
Analysis the change of gut microbiota before and after bowel preparation for colonoscopy, and the effect of probiotics.
次要结局
- The correlation between symptoms and gut microbiota..(eight months)
- The occurrence of symptoms(eight months)
研究者
Jae Hyun Kim
Assistant Professor
Kosin University Gospel Hospital