Anti COVID-19 Antibodies in Spermatic Fluid and Follicular Fluid
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Follicular - Serum Anti COVID-19 antibody (Immunoglobulin G) ratio
研究概览
简要总结
Patients going through an in vitro fertilization cycle will be asked to participate . Patients will be asked for their COVID-19 exposure : post confirmed disease/post vaccine/not exposed to disease or vaccine . Patients will provide the fluids which are not required , once fertilization process is completed. Patients will also provide 5ml blood sample by the day of procedure. Anti COVID-19 immunoglobulin G type antibodies will be measured in all samples . Data regarding age, date of infection/vaccine will be collected . Progesterone and Estrogen will be measured in female patients' samples and Perlecan level will be measured in follicular fluid.
详细描述
Patients going through an in vitro fertilization cycle will be asked to participate . Patients will be asked for their COVID-19 exposure : post confirmed disease/post vaccine/not exposed to disease or vaccine . Patients will provide the fluids which are not required in the day of egg retrieval : the follicular fluid remaining after isolation of the egg and spermatic fluid only, if not utilized for fertilization. The fluids will be collected once fertilization process is completed. Patients will also provide 5ml blood sample by the day of procedure. Anti COVID-19 immunoglobulin G type antibodies will be measured in all samples . Data regarding age, date of infection/vaccine will be collected as well as indication for treatment, Estradiol level before the egg retrieval, number of eggs collected and the triggering ovulation modality . Progesterone and Estrogen will be measured in female patients' samples (follicular fluid and serum). Perlecan level will be measured in follicular fluid.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned egg retrieval procedure (including egg preservation)
- •Negative PCR for SARS-Cov-19 in the week before egg retrival
- •Informed consent
排除标准
- •Positive PCR for SARS-Cov-19 in the week before egg retrival
- •expected retrival of 1-3 eggs
结局指标
主要结局
Follicular - Serum Anti COVID-19 antibody (Immunoglobulin G) ratio
时间窗: Through study completion, expected 2 months
The relationship between antibodies to COVID-19 in serum to follicular fluid in female patients going through an egg retrieval
Spermatic fluid- Serum Anti COVID-19 antibody (Immunoglobulin G) ratio
时间窗: Through study completion, expected 2 months
The relationship between antibodies to COVID-19 in serum to spermatic fluid in male patients going through in vitro fertilization treatment
次要结局
- Follicular fluid Estradiol level (pmol/L)(Through study completion, expected 2 months)
- Follicular fluid Progesterone level (nmol/L)(Through study completion, expected 2 months)
- Follicular fluid Perlecan level (nmol/L)(Through study completion, expected 2 months)
研究者
Anat Hershko Klement
Unit director
Meir Medical Center