Impact of Physical Exercise on Telomere Length and Other Markers of Premature Ageing in First-episode Psychosis.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- University of Salamanca
- Enrollment
- 40
- Primary Endpoint
- Telomere Length
Study Overview
Brief Summary
Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers. Physical exercise has shown protective effects in the general population, but there are no intervention studies in this population.
Objective: To evaluate the effect of a strength training programme on telomere length and other markers of cellular ageing in people with a first episode of psychosis.
Material and methods: Quasi-experimental study with patients aged 18-35 years included in the PRINT programme (Salamanca). Standard treatment will be compared with standard treatment plus a 12-week strength training programme. Telomere length (qPCR), inflammatory and senescence markers (proteomics), body composition, frailty and quality of life will be analysed.
Applicability: The results could support the inclusion of physical exercise programmes as a complementary intervention in early psychosis care, promoting overall health, quality of life and reducing the gap in life expectancy compared to the general population.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- Single (Outcomes Assessor)
Masking Description
The persons in charge of the evaluation of the participants will be unaware of the assignment of the participants.
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •be at least 18 years of age
- •Having experienced a first psychotic episode in the last 3 years
Exclusion Criteria
- •are unable to read and understand the patient information sheet and sign the informed consent form.
Outcomes
Primary Outcomes
Telomere Length
Time Frame: Baseline and immediately after the intervention
Telomere length will be measured before and after the procedure in kilobases.
Secondary Outcomes
- Fragility(Baseline and immediately after the intervention)
- Quality of life(Baseline and immediately after the intervention)
- Differential plasma profile(Baseline and immediately after the intervention)
Investigators
Juan Luis Sanchez Gonzalez
Principal investigator. Juan Luis Sánchez González
University of Salamanca