BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders (B-GLAD)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Generalized Anxiety Disorder
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- Change in Signal Intensity
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.
Detailed Description
The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.
Investigators
Matthias Friedrich
Principal Investigator
McGill University Health Centre/Research Institute of the McGill University Health Centre
Eligibility Criteria
Inclusion Criteria
- •Patient population:
- •Confirmation of an anxiety disorder as identified by the PSWQ,
- •No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression)
- •Non-smoker
- •Healthy Volunteers:
- •Age 18-55
- •No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system
- •Non-smoker
Exclusion Criteria
- •General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy
- •History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke)
- •Hemodynamically unstable conditions
- •Significant or uncontrolled arrhythmias
- •Severe pulmonary disease
- •Recent (\<90 days) myocardial infarction
- •Recent (\<90 days) surgery or coronary intervention
- •Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam
- •Use of benzodiazepines or other short-acting anxiety medications (\<1 day)
Outcomes
Primary Outcomes
Change in Signal Intensity
Time Frame: Baseline
Change in signal intensity between the baseline signal intensity and the signal intensity at 30 seconds of breath hold