Neuroimaging the Impact of Respiration and Respiratory-gated Neuromodulation on Human Glymphatic Physiology
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Boston University Charles River Campus
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- functional magnetic resonance imaging (fMRI) signals
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.
Detailed Description
Cerebrospinal fluid (CSF) flow is essential for brain health, as it clears waste products from the brain. This study will investigate how breathing affects the flow of CSF around the brain. The investigators will perform high resolution magnetic resonance imaging (MRI) scans in participants who are breathing in specific patterns or performing simple tasks and test the effects on CSF flow. Participants will complete an imaging study visit in which the investigators will image their brain activity while they perform simple tasks, including paced breathing tasks. The participants will be split into two arms: (1) paced breathing (25 participants low resolution, 15 participants high resolution), (2) transcutaneous vagal nerve stimulation (25 participants low resolution, 15 participants high resolution). The MRI scans will take place in the 7 Tesla MRI scanner at Massachusetts General Hospital.
Investigators
Laura Lewis
Assistant Professor
Boston University Charles River Campus
Eligibility Criteria
Inclusion Criteria
- •Adult age 18-70 years
Exclusion Criteria
- •No ferrous metal implanted in head or body
- •No history of major head trauma
- •No neurological or psychiatric disorder
- •Not using medication that affects brain function
- •No implanted electronic devices (e.g. pacemaker)
- •No implant that poses an MR contraindication
- •Not pregnant, suspect they are pregnant, or seeking to become pregnant
- •Not claustrophobic
- •No piercings or jewelry that cannot be removed
- •Does not weigh more than 250 pounds
Outcomes
Primary Outcomes
functional magnetic resonance imaging (fMRI) signals
Time Frame: During study (2 hours)
fMRI measures of hemodynamic responses. Units: percent signal change
Cerebrospinal fluid (CSF) signals
Time Frame: During study (2 hours)
MR-based measures of CSF signals. Units: percent signal change
Secondary Outcomes
- Pulse oximetry(During study ( 2 hours))
- Heart rate(During study ( 2 hours))
- Respiratory physiology timing(During study (2 hours))
- Respiratory physiology amplitude(During study (2 hours))